Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats

Objective Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet‐induced obese (DIO) and diet‐resistant (DR) rats. Methods Adult, male DIO, and DR rats were randomized to: high‐fat/high‐sucrose (HFS) diet or HFS diet + 10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB1 receptor expression in the nodose ganglia were measured. Results OFS reduced body weight, energy intake, and fat mass in both phenotypes (P