Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients

Highlights • First identification of two distinct HPA axis reactivity subgroups of PTSD. • These two subgroups exhibited distinct clinical and biological characteristics. • One subgroup largely drove the diminished HPA axis response of the total PTSD cohort.

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Bibliographische Detailangaben
Veröffentlicht in:	Psychoneuroendocrinology 2015-05, Vol.55, p.102-115
Hauptverfasser:	Zaba, Monika, Kirmeier, Thomas, Ionescu, Irina A, Wollweber, Bastian, Buell, Dominik R, Gall-Kleebach, Dominique J, Schubert, Christine F, Novak, Bozidar, Huber, Christine, Köhler, Katharina, Holsboer, Florian, Pütz, Benno, Müller-Myhsok, Bertram, Höhne, Nina, Uhr, Manfred, Ising, Marcus, Herrmann, Leonie, Schmidt, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - metabolism Adult Adult Survivors of Child Adverse Events Case-Control Studies Cohort Studies Endocrinology & Metabolism Endophenotypes Female FKBP5 Gene expression Humans Hydrocortisone - metabolism Hypothalamo-Hypophyseal System - metabolism Middle Aged Pituitary-Adrenal System - metabolism Posttraumatic stress disorder Psychiatry PTSD PTSD subtypes Receptors, Glucocorticoid - genetics Receptors, Mineralocorticoid - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Stress Disorders, Post-Traumatic - genetics Stress Disorders, Post-Traumatic - metabolism Stress Disorders, Post-Traumatic - psychology Stress reactivity Stress, Psychological - genetics Stress, Psychological - metabolism Stress, Psychological - psychology Tacrolimus Binding Proteins - genetics Transcriptome Trier Social Stress Test
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Beschreibung
Zusammenfassung:	Highlights • First identification of two distinct HPA axis reactivity subgroups of PTSD. • These two subgroups exhibited distinct clinical and biological characteristics. • One subgroup largely drove the diminished HPA axis response of the total PTSD cohort.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2015.02.005