Radical Cystectomy and Adjuvant Chemotherapy for Bladder Cancer in the Elderly: A Population-based Study

Objective To assess radical cystectomy (RC) outcomes and adjuvant chemotherapy (ACT) use in the elderly in routine practice. Bladder cancer occurs most commonly in the elderly. RC, standard treatment for muscle-invasive bladder cancer, presents challenges in older patients. Suboptimal evidence guide...

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Veröffentlicht in:	Urology (Ridgewood, N.J.) N.J.), 2015-04, Vol.85 (4), p.791-798
Hauptverfasser:	Leveridge, Michael J, Siemens, D. Robert, Mackillop, William J, Peng, Yingwei, Tannock, Ian F, Berman, David M, Booth, Christopher M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Blood Vessels - pathology Carboplatin - therapeutic use Carcinoma - epidemiology Carcinoma - secondary Carcinoma - therapy Chemotherapy, Adjuvant - trends Cisplatin - therapeutic use Cystectomy - trends Female Humans Length of Stay - statistics & numerical data Lymph Node Excision Lymphatic Metastasis Lymphatic Vessels - pathology Male Neoadjuvant Therapy - trends Neoplasm Invasiveness Neoplasm Staging Ontario - epidemiology Patient Readmission - statistics & numerical data Registries Socioeconomic Factors Survival Rate Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - epidemiology Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery Urology
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Zusammenfassung:	Objective To assess radical cystectomy (RC) outcomes and adjuvant chemotherapy (ACT) use in the elderly in routine practice. Bladder cancer occurs most commonly in the elderly. RC, standard treatment for muscle-invasive bladder cancer, presents challenges in older patients. Suboptimal evidence guides ACT use. Methods All patients undergoing RC for urothelial cancer in Ontario from 1994 to 2008 were identified using the Ontario Cancer Registry. Pathology reports and treatment records were linked to the database. Patients were age stratified as
ISSN:	0090-4295 1527-9995
DOI:	10.1016/j.urology.2014.12.027