Representational similarity analysis offers a preview of the noradrenergic modulation of long-term fear memory at the time of encoding

Highlights • Here we combined fMRI with fear conditioning to find markers for memory formation. • Salivary alpha-amylase (sAA) revealed a rise in sympathetic activation prior to scanning. • This rise in sAA predicted the subsequent expression of fear (48 h later). • Neural pattern similarity was rel...

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Veröffentlicht in:	Psychoneuroendocrinology 2015-05, Vol.55, p.8-20
Hauptverfasser:	Visser, Renée M, Kunze, Anna E, Westhoff, Bianca, Scholte, H. Steven, Kindt, Merel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenergic alpha-2 Receptor Antagonists - pharmacology Amygdala - drug effects Amygdala - physiology Brain - drug effects Brain - physiology Cerebral Cortex - drug effects Cerebral Cortex - physiology Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology Double-Blind Method Endocrinology & Metabolism Fear - drug effects Fear - physiology Fear conditioning Female fMRI Functional Neuroimaging Gyrus Cinguli - drug effects Gyrus Cinguli - physiology Hippocampus - drug effects Hippocampus - physiology Humans Magnetic Resonance Imaging Male Memory, Long-Term - drug effects Memory, Long-Term - physiology Multi-voxel pattern analysis Noradrenergic activation Norepinephrine - physiology Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Psychiatry Pupil - drug effects Pupil - physiology Random Allocation Recognition (Psychology) Reflex, Startle - drug effects Reflex, Startle - physiology Representational similarity analysis Saliva - chemistry Salivary alpha-Amylases - analysis Salivary alpha-Amylases - drug effects Salivary α-amylase Yohimbine - pharmacology Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Here we combined fMRI with fear conditioning to find markers for memory formation. • Salivary alpha-amylase (sAA) revealed a rise in sympathetic activation prior to scanning. • This rise in sAA predicted the subsequent expression of fear (48 h later). • Neural pattern similarity was related to sAA and the subsequent expression of fear. • Representational similarity analysis yields markers for (enhanced) fear memory formation.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2015.01.021