Synthesis of mutagenic 2,4-dinitro-[7-14C]benzaldehyde

2,4‐Dinitro‐[7‐14C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐14C]toluene to give an overall radiochemical yield...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1994-07, Vol.34 (7), p.597-601
Hauptverfasser:	Shoji, Miki, Mori, Masa-Aki, Sayama, Michio, Kozuka, Hiroshi, Honda, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4‐dinitro‐[7‐14C]benzaldehyde 4-dinitro-[7-14C]benzaldehyde Chemistry Exact sciences and technology mutagen Noncondensed benzenic compounds Organic chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	2,4‐Dinitro‐[7‐14C]benzaldehyde (4), a mutagenic substance which may have an unique metabolic activating pathways, was synthesized as a tracer for the detection of adducts of 4 with macromolecules. The preparation was performed in four steps from [7‐14C]toluene to give an overall radiochemical yield of 20% after purifying by TLC. The radiochemical purity was over 98%.
ISSN:	0362-4803 1099-1344
DOI:	10.1002/jlcr.2580340703