TAN-1057 A similar to D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus . Taxonomy, fermentation and biological activity

TAN-1057 A similar to D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus . Taxonomy, fermentation and biological activity

Two Gram-negative bacteria were found to produce the new antibacterial antibiotics TAN-1057 A, B, C and D. The producing bacteria were characterized and designated as Flexibacter sp. PK-74 and PK-176. These antibiotics were active against Gram-negative and Gram-positive bacteria, including methicill...

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Veröffentlicht in:Journal of antibiotics 1993-01, Vol.46 (4), p.606-613
Hauptverfasser: Katayama, N, Fukusumi, S, Funabashi, Y, Iwahi, T, Ono, H
Format: Artikel
Sprache:eng
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Zusammenfassung:Two Gram-negative bacteria were found to produce the new antibacterial antibiotics TAN-1057 A, B, C and D. The producing bacteria were characterized and designated as Flexibacter sp. PK-74 and PK-176. These antibiotics were active against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus . TAN-1057 A inhibited protein biosynthesis in Escherichia coli and S. aureus . It showed excellent protective effects against an experimental methicillin-resistant S. aureus infection in mice.
ISSN:0021-8820