RNA Sequencing Analysis Identifies New Human Collagen Genes Involved in Cardiac Remodeling

In HF, remodeling initially occurs as a compensatory response to preserve the structural integrity of the myocardium, but progressive collagen deposition can lead to cardiac fibrosis and impairment of diastolic and systolic function (1). [...]we analyzed changes in the expression profile of collagen-related genes in patients with ischemic cardiomyopathy (ICM) and examined the relationships with left ventricular (LV) dysfunction. Inhibition of collagen remodeling can lead to improved cardiac function, demonstrating the relevance of new insights into the compensatory remodeling mechanism. [...]our findings give new theoretical support for the treatment of patients with ischemic cardiomyopathy.