Shorter halving time of BCR‐ABL1 transcripts is a novel predictor for achievement of molecular responses in newly diagnosed chronic‐phase chronic myeloid leukemia treated with dasatinib: Results of the D‐first study of Kanto CML study group

To investigate the factors that affect molecular responses on dasatinib treatment in patients with chronic‐phase chronic myeloid leukemia (CML‐CP), we performed a clinical trial named the “D‐First study.” Fifty‐two patients with newly diagnosed CML‐CP were enrolled in this study and received 100 mg...

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Veröffentlicht in:American journal of hematology 2015-04, Vol.90 (4), p.282-287
Hauptverfasser: Iriyama, Noriyoshi, Fujisawa, Shin, Yoshida, Chikashi, Wakita, Hisashi, Chiba, Shigeru, Okamoto, Shinichiro, Kawakami, Kimihiro, Takezako, Naoki, Kumagai, Takashi, Inokuchi, Koiti, Ohyashiki, Kazuma, Taguchi, Jun, Yano, Shingo, Igarashi, Tadahiko, Kouzai, Yasuji, Morita, Satoshi, Sakamoto, Junichi, Sakamaki, Hisashi
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Sprache:eng
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Zusammenfassung:To investigate the factors that affect molecular responses on dasatinib treatment in patients with chronic‐phase chronic myeloid leukemia (CML‐CP), we performed a clinical trial named the “D‐First study.” Fifty‐two patients with newly diagnosed CML‐CP were enrolled in this study and received 100 mg dasatinib once daily. A deep molecular response (DMR) was defined as
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.23923