Overexpression of GYS1, MIF , and MYC Is Associated With Adverse Outcome and Poor Response to Azacitidine in Myelodysplastic Syndromes and Acute Myeloid Leukemia

Micro-Abstract Molecular abnormalities are critical in prognosis of myeloid malignancies. We evaluated the impact of gene expression in 81 patients with MDS and AML. Over-expression of some of these genes was related to poor outcome ( GYS1 and MIF ) and lower response to azacitidine ( MYC ). Validat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2015-04, Vol.15 (4), p.236-244
Hauptverfasser:	Falantes, Jose F, Trujillo, Pablo, Piruat, Jose I, Calderón, Cristina, Márquez-Malaver, Francisco J, Martín-Antonio, Beatriz, Millán, Africa, Gómez, Marina, González, Jose, Martino, Maria L, Montero, Isabel, Parody, Rocío, Espigado, Ildefonso, Urbano-Ispizua, Alvaro, Pérez-Simón, Jose A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute leukemia Aged Aged, 80 and over Antimetabolites, Antineoplastic - therapeutic use Azacitidine Azacitidine - therapeutic use Gene Expression Gene Expression Profiling Genes, myc Glycogen Synthase - genetics Hematology, Oncology and Palliative Medicine Humans Hypoxia - genetics Intramolecular Oxidoreductases - genetics Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Macrophage Migration-Inhibitory Factors - genetics Middle Aged Myelodysplastic syndromes Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - mortality Prognosis Survival Analysis Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Micro-Abstract Molecular abnormalities are critical in prognosis of myeloid malignancies. We evaluated the impact of gene expression in 81 patients with MDS and AML. Over-expression of some of these genes was related to poor outcome ( GYS1 and MIF ) and lower response to azacitidine ( MYC ). Validation of these results could translate in prognosis refinement and treatment decision.
ISSN:	2152-2650 2152-2669
DOI:	10.1016/j.clml.2014.10.003