Effect of Sulphur Mustard on mouse skin : an electron microscopic evaluation
Sulfur mustard was applied to clipped areas on the dorso caudal surface of male Swiss Albino mice. The animals were sacrificed on day 1, 3, and 6, and analyzed microscopically. Both epidermal and dermal cells were examined. Following application of sulfur mustard, the architectural order of the epid...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 1993-09, Vol.51 (3), p.374-380 |
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| container_title | Bulletin of environmental contamination and toxicology |
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| creator | CHAUHAN, R. S MURTHY, L. V. R MALHOTRA, R. C |
| description | Sulfur mustard was applied to clipped areas on the dorso caudal surface of male Swiss Albino mice. The animals were sacrificed on day 1, 3, and 6, and analyzed microscopically. Both epidermal and dermal cells were examined. Following application of sulfur mustard, the architectural order of the epidermal region was disturbed compared to controls. The discrete cell boundaries were distorted, showing necrotic epidermal cells with cytoplasmic vacuoles. With extended exposure, contiguous microholes were revealed in the stratified layers of the epidermis. The nuclear membrane at the upper dermis showed loss of integrity, and cytoplasmic vacuoles were seen frequently. Ultrastructural analysis revealed that the process of skin recovery began on the third day, and was perceptible on the sixth day when the epidermal tissues became aligned in parallel layers. |
| doi_str_mv | 10.1007/BF00201755 |
| format | Article |
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Ultrastructural analysis revealed that the process of skin recovery began on the third day, and was perceptible on the sixth day when the epidermal tissues became aligned in parallel layers.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/BF00201755</identifier><identifier>PMID: 8219592</identifier><identifier>CODEN: BECTA6</identifier><language>eng</language><publisher>New York, NY: Springer-Verlag</publisher><subject>Animals ; Basement Membrane - drug effects ; Basement Membrane - ultrastructure ; Biological and medical sciences ; Chemical and industrial products toxicology. 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S</creatorcontrib><creatorcontrib>MURTHY, L. V. R</creatorcontrib><creatorcontrib>MALHOTRA, R. C</creatorcontrib><title>Effect of Sulphur Mustard on mouse skin : an electron microscopic evaluation</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><description>Sulfur mustard was applied to clipped areas on the dorso caudal surface of male Swiss Albino mice. The animals were sacrificed on day 1, 3, and 6, and analyzed microscopically. Both epidermal and dermal cells were examined. Following application of sulfur mustard, the architectural order of the epidermal region was disturbed compared to controls. The discrete cell boundaries were distorted, showing necrotic epidermal cells with cytoplasmic vacuoles. With extended exposure, contiguous microholes were revealed in the stratified layers of the epidermis. The nuclear membrane at the upper dermis showed loss of integrity, and cytoplasmic vacuoles were seen frequently. Ultrastructural analysis revealed that the process of skin recovery began on the third day, and was perceptible on the sixth day when the epidermal tissues became aligned in parallel layers.</description><subject>Animals</subject><subject>Basement Membrane - drug effects</subject><subject>Basement Membrane - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Epithelium - drug effects</subject><subject>Epithelium - ultrastructure</subject><subject>Extracellular Matrix - drug effects</subject><subject>Extracellular Matrix - ultrastructure</subject><subject>Gas, fumes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mustard Gas - toxicity</subject><subject>Skin - drug effects</subject><subject>Skin - ultrastructure</subject><subject>Toxicology</subject><subject>Wound Healing</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAUhS0EKqWwsCN5QAxIAT9jhw2qFpCKGOgeOc61COSFnSDx70nUqIxMd_g-HZ17EDqn5IYSom4f1oQwQpWUB2hOBWcR0YQcojkZaCR0TI_RSQgfhFCpGZuhmWY0kQmbo83KObAdbhx-68v2vff4pQ-d8Tlualw1fQAcPosa32FTYygH14-gsL4JtmkLi-HblL3piqY-RUfOlAHOprtA2_Vqu3yKNq-Pz8v7TWS54l1kVQYGhOUi0VxbrXIDEoTIeCKEABNzpXWurXS5glxIHoM2kGmgTnMm-QJd7WJb33z1ELq0KoKFsjQ1DIVTGseKJYT8LwrOGU_GxOudOH4VPLi09UVl_E9KSTpOnP5NPMgXU2qfVZDv1WnTgV9O3ARrSudNbYuw1wTlivGY_wIr2YIn</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>CHAUHAN, R. 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Toxic occupational diseases</topic><topic>Epithelium - drug effects</topic><topic>Epithelium - ultrastructure</topic><topic>Extracellular Matrix - drug effects</topic><topic>Extracellular Matrix - ultrastructure</topic><topic>Gas, fumes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mustard Gas - toxicity</topic><topic>Skin - drug effects</topic><topic>Skin - ultrastructure</topic><topic>Toxicology</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHAUHAN, R. S</creatorcontrib><creatorcontrib>MURTHY, L. V. R</creatorcontrib><creatorcontrib>MALHOTRA, R. 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With extended exposure, contiguous microholes were revealed in the stratified layers of the epidermis. The nuclear membrane at the upper dermis showed loss of integrity, and cytoplasmic vacuoles were seen frequently. Ultrastructural analysis revealed that the process of skin recovery began on the third day, and was perceptible on the sixth day when the epidermal tissues became aligned in parallel layers.</abstract><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>8219592</pmid><doi>10.1007/BF00201755</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Basement Membrane - drug effects Basement Membrane - ultrastructure Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Epithelium - drug effects Epithelium - ultrastructure Extracellular Matrix - drug effects Extracellular Matrix - ultrastructure Gas, fumes Male Medical sciences Mice Mustard Gas - toxicity Skin - drug effects Skin - ultrastructure Toxicology Wound Healing |
| title | Effect of Sulphur Mustard on mouse skin : an electron microscopic evaluation |
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