Nucleoside antibiotics: biosynthesis, regulation, and biotechnology

Highlights • Nucleoside antibiotics are broad-spectrum antibiotics with unique structural features. • Unusual enzymatic reactions occur in the biosynthesis of nucleoside antibiotics. • Biosynthesis of nucleoside antibiotics is regulated at multiple levels. • Biosynthetic studies may assist with rati...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2015-02, Vol.23 (2), p.110-119
Hauptverfasser:	Niu, Guoqing, Tan, Huarong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides - biosynthesis Aminoglycosides - chemistry Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Antifungal Agents - chemistry Antifungal Agents - metabolism Antiviral Agents - chemistry Antiviral Agents - metabolism biosynthesis Biotechnology Cytidine - analogs & derivatives Cytidine - biosynthesis Cytosine - analogs & derivatives Cytosine - biosynthesis Cytosine - chemistry Genetic Engineering Internal Medicine nucleoside antibiotics Nucleosides - biosynthesis Nucleosides - chemistry Nucleosides - metabolism Pyrimidine Nucleosides - biosynthesis Pyrimidine Nucleosides - chemistry regulation
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Beschreibung
Zusammenfassung:	Highlights • Nucleoside antibiotics are broad-spectrum antibiotics with unique structural features. • Unusual enzymatic reactions occur in the biosynthesis of nucleoside antibiotics. • Biosynthesis of nucleoside antibiotics is regulated at multiple levels. • Biosynthetic studies may assist with rational design of novel antibacterial agents.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2014.10.007