CXCL8, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis

Highlights • CXCL8 and TOPK were elevated in colorectal cancer (CRC). • High CXCL8 and TOPK expression levels were correlated with poor prognosis of CRC. • CXCL8 is strongly implicated in the resistance of CRC cells to anoikis through regulating AKT, TOPK and ERK pathways.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2015-05, Vol.361 (1), p.22-32
Hauptverfasser:	Xiao, You-Chuan, Yang, Zhi-Bin, Cheng, Xian-Shuo, Fang, Xing-Bao, Shen, Tao, Xia, Cui-Feng, Liu, Ping, Qian, Hai-Hua, Sun, Bin, Yin, Zheng-Feng, Li, Yun-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - secondary Adolescent Adult Aged Aged, 80 and over Angiogenesis Anoikis Apoptosis Biomarkers, Tumor - metabolism Blotting, Western Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology CXCL-8 Family medical history Female Fluorescent Antibody Technique Follow-Up Studies Hematology, Oncology and Palliative Medicine Humans Immunoenzyme Techniques Interleukin-8 - metabolism Kinases Liver Neoplasms - metabolism Liver Neoplasms - secondary Lymphatic Metastasis Male Medical prognosis Metastasis Middle Aged Mitogen-Activated Protein Kinase Kinases - metabolism Neoplasm Grading Neoplasm Invasiveness Prognosis Proto-Oncogene Proteins c-akt - metabolism Signal Transduction TOPK Tumor Cells, Cultured Young Adult
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Beschreibung
Zusammenfassung:	Highlights • CXCL8 and TOPK were elevated in colorectal cancer (CRC). • High CXCL8 and TOPK expression levels were correlated with poor prognosis of CRC. • CXCL8 is strongly implicated in the resistance of CRC cells to anoikis through regulating AKT, TOPK and ERK pathways.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.02.021