Pre-treatment with probiotics prolongs survival after experimental infection by multidrug-resistant Pseudomonas aeruginosa in rodents: An effect on sepsis-induced immunosuppression

Highlights • Pre-treatment with Lactobacillus plantarum protects from lethal experimental infections. • A mixture of four probiotics provides similar survival benefit. • Partial restoration of cytokine production is observed. • The action is mediated through suppression of SOCS3 expression.

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of antimicrobial agents 2015-04, Vol.45 (4), p.376-384
Hauptverfasser:	Machairas, Nikolaos, Pistiki, Aikaterini, Droggiti, Dionyssia-Irini, Georgitsi, Marianna, Pelekanos, Nikolaos, Damoraki, Georgia, Kouraklis, Grigorios, Giamarellos-Bourboulis, Evangelos J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cytokines - secretion Drug Resistance, Multiple, Bacterial Healthy Volunteers Humans Immune Tolerance Infectious Disease Interleukin-10 Leukocytes, Mononuclear - immunology Male Mice, Inbred C57BL Probiotics Probiotics - administration & dosage Pseudomonas aeruginosa Pseudomonas aeruginosa - immunology Pseudomonas Infections - immunology Pseudomonas Infections - therapy Sepsis Sepsis - immunology Sepsis - therapy SOCS3 Survival Analysis Tumour necrosis factor-alpha
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Beschreibung
Zusammenfassung:	Highlights • Pre-treatment with Lactobacillus plantarum protects from lethal experimental infections. • A mixture of four probiotics provides similar survival benefit. • Partial restoration of cytokine production is observed. • The action is mediated through suppression of SOCS3 expression.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2014.11.013