Incidence and Long-term Outcomes of the Human Immunodefıciency Virus Neuroretinal Disorder in Patients with AIDS

Purpose Patients with AIDS have an abnormality of retina/optic nerve function, manifested as decreased contrast sensitivity (in the absence of ocular opportunistic infections or media opacity), abnormalities on automated perimetry, and loss of retinal nerve fiber layer, even among those with good visual acuity, termed the “human immunodeficiency virus (HIV) neuroretinal disorder.” The objectives of this study were to determine the prevalence, incidence, risk factors, and outcomes of HIV neuroretinal disorder. Design Prospective cohort study. Participants A total of 1822 patients with AIDS without ocular infections or media opacities. Methods Patients with HIV neuroretinal disorder were identified by a contrast sensitivity