Pulmonary surfactant in the airway physiology: A direct relaxing effect on the smooth muscle
Highlights • Airway surfactant has an important role in the respiratory physiology. • Surfactant directly relaxes airway smooth muscle. • Surfactant dysfunction may be included in the pathophysiology of asthma, COPD or other diseases with bronchial obstruction.
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| Veröffentlicht in: | Respiratory physiology & neurobiology 2015-04, Vol.209, p.95-105 |
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| container_title | Respiratory physiology & neurobiology |
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| creator | Calkovska, A Uhliarova, B Joskova, M Franova, S Kolomaznik, M Calkovsky, V Smolarova, S |
| description | Highlights • Airway surfactant has an important role in the respiratory physiology. • Surfactant directly relaxes airway smooth muscle. • Surfactant dysfunction may be included in the pathophysiology of asthma, COPD or other diseases with bronchial obstruction. |
| doi_str_mv | 10.1016/j.resp.2015.01.004 |
| format | Article |
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Uhliarova, B ; Joskova, M ; Franova, S ; Kolomaznik, M ; Calkovsky, V ; Smolarova, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-ab8fc9b061061e48cb53fb18ce08f1a520edd65f2e11347f5d6fa1ad49531d583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biological Products - pharmacology</topic><topic>Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors</topic><topic>Cystic Fibrosis Transmembrane Conductance Regulator - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Glyburide - pharmacology</topic><topic>Glycine - analogs & derivatives</topic><topic>Glycine - pharmacology</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Hydrazines - pharmacology</topic><topic>KATP Channels - antagonists & inhibitors</topic><topic>KATP Channels - metabolism</topic><topic>Lung - drug effects</topic><topic>Lung - physiology</topic><topic>Medical Education</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle Relaxation - physiology</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Obstruction</topic><topic>Phospholipids - pharmacology</topic><topic>Pulmonary surfactant</topic><topic>Pulmonary Surfactants - pharmacology</topic><topic>Pulmonary/Respiratory</topic><topic>Relaxation</topic><topic>Smooth muscle</topic><topic>Tissue Culture Techniques</topic><topic>Trachea - drug effects</topic><topic>Trachea - physiology</topic><topic>Upper and lower airways</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calkovska, A</creatorcontrib><creatorcontrib>Uhliarova, B</creatorcontrib><creatorcontrib>Joskova, M</creatorcontrib><creatorcontrib>Franova, S</creatorcontrib><creatorcontrib>Kolomaznik, M</creatorcontrib><creatorcontrib>Calkovsky, V</creatorcontrib><creatorcontrib>Smolarova, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory physiology & neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calkovska, A</au><au>Uhliarova, B</au><au>Joskova, M</au><au>Franova, S</au><au>Kolomaznik, M</au><au>Calkovsky, V</au><au>Smolarova, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary surfactant in the airway physiology: A direct relaxing effect on the smooth muscle</atitle><jtitle>Respiratory physiology & neurobiology</jtitle><addtitle>Respir Physiol Neurobiol</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>209</volume><spage>95</spage><epage>105</epage><pages>95-105</pages><issn>1569-9048</issn><eissn>1878-1519</eissn><abstract>Highlights • Airway surfactant has an important role in the respiratory physiology. • Surfactant directly relaxes airway smooth muscle. • Surfactant dysfunction may be included in the pathophysiology of asthma, COPD or other diseases with bronchial obstruction.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25583659</pmid><doi>10.1016/j.resp.2015.01.004</doi><tpages>11</tpages></addata></record> |
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| ispartof | Respiratory physiology & neurobiology, 2015-04, Vol.209, p.95-105 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological Products - pharmacology Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Glyburide - pharmacology Glycine - analogs & derivatives Glycine - pharmacology Guinea Pigs Humans Hydrazines - pharmacology KATP Channels - antagonists & inhibitors KATP Channels - metabolism Lung - drug effects Lung - physiology Medical Education Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth - drug effects Muscle, Smooth - physiology NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Obstruction Phospholipids - pharmacology Pulmonary surfactant Pulmonary Surfactants - pharmacology Pulmonary/Respiratory Relaxation Smooth muscle Tissue Culture Techniques Trachea - drug effects Trachea - physiology Upper and lower airways |
| title | Pulmonary surfactant in the airway physiology: A direct relaxing effect on the smooth muscle |
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