Prothrombin Complex Concentrates in Trauma and Perioperative Bleeding

There is increasing interest in prothrombin complex concentrates as therapy for perioperative and trauma-related bleeding. A suitable point-of-care test is needed to guide such therapy, and randomized controlled trials are needed for robust, evidence-based recommendations.

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Bibliographische Detailangaben
Veröffentlicht in:	Anesthesiology (Philadelphia) 2015-04, Vol.122 (4), p.923-931
Hauptverfasser:	Grottke, Oliver, Levy, Jerrold H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Coagulation - drug effects Blood Coagulation Factors - pharmacology Blood Coagulation Factors - therapeutic use Humans Postoperative Hemorrhage - diagnosis Postoperative Hemorrhage - physiopathology Wounds and Injuries - drug therapy Wounds and Injuries - physiopathology
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Beschreibung
Zusammenfassung:	There is increasing interest in prothrombin complex concentrates as therapy for perioperative and trauma-related bleeding. A suitable point-of-care test is needed to guide such therapy, and randomized controlled trials are needed for robust, evidence-based recommendations.
ISSN:	0003-3022 1528-1175
DOI:	10.1097/ALN.0000000000000608