Effect of Ribavirin on Hela Cells Expressing E. coli Xanthine-Guanine Phosphoribosyl Transferase

HeLa cells expressing the E. coli gene Ecogpt and cultured with xanthine were extremely resistant to antiproliferation by mycophenolic acid, but were only partially resistant to the effects of ribavirin. Nucleotide analyses of these transfected cells, and the parental HeLa cells, demonstrated an ass...

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Veröffentlicht in:	Antiviral chemistry & chemotherapy 1993-08, Vol.4 (4), p.249-252
Hauptverfasser:	Andersen, D. O., Murray, B. K., North, J. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences E coli Escherichia coli Guanine Guanosine triphosphate Medical sciences Mycophenolic acid Pharmacology. Drug treatments Ribavirin Xanthines
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Zusammenfassung:	HeLa cells expressing the E. coli gene Ecogpt and cultured with xanthine were extremely resistant to antiproliferation by mycophenolic acid, but were only partially resistant to the effects of ribavirin. Nucleotide analyses of these transfected cells, and the parental HeLa cells, demonstrated an association between the GTP/ribavirin triphosphate ratio and virus yield reductions.
ISSN:	2040-2066 0956-3202 2040-2066
DOI:	10.1177/095632029300400409