Preferential enlargement of leukemia cells using cytoskeletal-directed agents and cell cycle growth control parameters to induce sensitivity to low frequency ultrasound

Highlights • Leukemia cells are preferentially damaged based on size. • Cytoskeletal-directed agents can increase ultrasonic sensitivity. • Cytoskeletal-disrupting agents substantially increase cell death in leukemia. • Cytochalasin B and vincristine may be used in combination to increase sensitivit...

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Veröffentlicht in:	Cancer letters 2015-05, Vol.360 (2), p.160-170
Hauptverfasser:	Trendowski, Matthew, Wong, Victoria, Zoino, Joseph N, Christen, Timothy D, Gadeberg, Lauren, Sansky, Michelle, Fondy, Thomas P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Bone marrow Cell Cycle - drug effects Cell Death - drug effects Cell growth Cell Growth Processes - physiology Cell-cycle synchronization Chemotherapy Cloning Culture Media, Serum-Free Cytochalasin B - pharmacology Cytoskeletal-directed agents Cytoskeleton - drug effects Depsipeptides - pharmacology Drug resistance Efficiency Hematology Hematology, Oncology and Palliative Medicine Humans Leukemia Leukemia - diagnostic imaging Leukemia - drug therapy Leukemia - pathology Leukemia - therapy Leukemia L1210 - diagnostic imaging Leukemia L1210 - drug therapy Leukemia L1210 - pathology Leukemia L1210 - therapy Mice Microtubules - drug effects Paclitaxel - pharmacology Sonodynamic therapy Stem cells Studies Transplants & implants U937 Cells Ultrasonic imaging Ultrasonic Therapy Ultrasonography Ultrasound Vincristine - pharmacology
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Zusammenfassung:	Highlights • Leukemia cells are preferentially damaged based on size. • Cytoskeletal-directed agents can increase ultrasonic sensitivity. • Cytoskeletal-disrupting agents substantially increase cell death in leukemia. • Cytochalasin B and vincristine may be used in combination to increase sensitivity.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.02.001