Prednisone for acute virus-associated wheeze in children: Panacea or one more brick in the wall?

In 2007, the Joint Commission created a national standard on the inpatient care of children admitted to the hospital for asthma that included a course of systemic corticosteroids as a quality indicator.10 This issue of the Journal of Allergy and Clinical Immunology includes the first placebo-controlled randomized clinical trial conducted by Jartti et al11 to address the effectiveness of prednisolone treatment for the first acute wheeze episode in young children infected with human rhinovirus.