4,6,4′-Trimethylangelicin induces interstrand cross-links in mammalian cell DNA
4,6,4′-Trimethylangelicin, a well-known effective photosensitizer described as a pure monofunctional reactant with DNA, can induce interstrand cross-links in mammalian cell DNA in vivo (about 15% relative to 8-methoxypsoralen), as observed using alkaline elution and Chinese hamster ovary cells. Expe...
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Veröffentlicht in: | Journal of photochemistry and photobiology. B, Biology Biology, 1994, Vol.26 (2), p.197-201 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | 4,6,4′-Trimethylangelicin, a well-known effective photosensitizer described as a pure monofunctional reactant with DNA, can induce interstrand cross-links in mammalian cell DNA in vivo (about 15% relative to 8-methoxypsoralen), as observed using alkaline elution and Chinese hamster ovary cells. Experiments performed using the two-step irradiation method and HeLa cells support these data. In contrast with 4,6,4′-trimethylangelicin, 4′-methylangelicin and 4,4′-dimethylangelicin do not form interstrand cross-links. These results are consistent with those recently reported by Chen et al. (X. Chen, J. Kagan, F. Dall'Acqua, D. Averbeck and E. Bisagni,
J. Photochem. Photobiol. B: Biol., 22 (1994) 51–57) using pBR322 and M13 DNA. The cross-linking ability of 4,6,4′-trimethylangelicin does not seem to be related to a particular feature of these DNAs but to the compound itself. |
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ISSN: | 1011-1344 1873-2682 |
DOI: | 10.1016/1011-1344(94)07040-7 |