Peri-conception parental obesity, reproductive health, and transgenerational impacts

Peri-conception parental obesity, reproductive health, and transgenerational impacts

Highlights • Maternal obesity changes oocyte composition altering lipid content and mitochondrial function. • Maternal obesity-induced changes impact on embryo development, programming disease risk in offspring. • Paternal obesity at conception impairs the metabolic and reproductive health of the of...

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Veröffentlicht in:Trends in endocrinology and metabolism 2015-02, Vol.26 (2), p.84-90
Hauptverfasser: Lane, Michelle, Zander-Fox, Deirdre L, Robker, Rebecca L, McPherson, Nicole O
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Endocrinology & Metabolism
epigenetic
Female
fertilization
Humans
Life Style
Maternal Nutritional Physiological Phenomena
Obesity - complications
Obesity - epidemiology
oocyte
Parents
preconception
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Prenatal Exposure Delayed Effects - etiology
Reproductive Health
Risk Factors
sperm
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Beschreibung
Zusammenfassung:Highlights • Maternal obesity changes oocyte composition altering lipid content and mitochondrial function. • Maternal obesity-induced changes impact on embryo development, programming disease risk in offspring. • Paternal obesity at conception impairs the metabolic and reproductive health of the offspring through two generations. • Paternal obesity alters epigenetic marks in sperm implicating these changes in the transmission of paternal health cues to the next generation.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2014.11.005