Nucleotide sequence of a cDNA encoding mouse cathepsin D

Nucleotide sequence of a cDNA encoding mouse cathepsin D

We report the nucleotide sequence of mouse cathepsin D mRNA derived from clones in a lambda gt10 cDNA library constructed from C57BL/6J mouse brain. Cathepsin D is a lysosomal aspartyl protease, and this cDNA was isolated while screening for upregulated genes in scrapie. The sequence is 1893 bp and...

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Veröffentlicht in:Nucleic acids research 1990-12, Vol.18 (23), p.7184-7184
Hauptverfasser: Diedrich, J F, Staskus, KA, Retzel, E F, Haase, A T
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Sprache:eng
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Zusammenfassung:We report the nucleotide sequence of mouse cathepsin D mRNA derived from clones in a lambda gt10 cDNA library constructed from C57BL/6J mouse brain. Cathepsin D is a lysosomal aspartyl protease, and this cDNA was isolated while screening for upregulated genes in scrapie. The sequence is 1893 bp and contains an open reading frame of 1230 bp with an initiation codon at nucleotide position 7 and a termination codon at 1237. The predicted amino acid sequence (410 aa) shows 81% similarity with the human kidney cathepsin D and 82% with the porcine spleen cathepsin D. (DBO)
ISSN:0305-1048
DOI:10.1093/nar/18.23.7184