Novel azoles as potent and selective cannabinoid CB2 receptor agonists

[Display omitted] Novel azole compounds were prepared which demonstrated potent hCB2 binding activities with antioxidant activity for a selected compound. These compounds show good selectivity over the hCB1 receptor and are full agonists at the hCB2 receptor.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-01, Vol.25 (1), p.88-91
Hauptverfasser:	Harnett, Jeremiah J., Dolo, Christine, Viossat, Isabelle, Auger, Florence, Ferrandis, Eric, Bigg, Dennis, Auguet, Michel, Auvin, Serge, Chabrier, Pierre-E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Azoles - chemistry Azoles - metabolism Cannabinoid agonists Cannabinoid Receptor Agonists - chemistry Cannabinoid Receptor Agonists - metabolism Cannabinoids - chemistry Cannabinoids - metabolism Chimeric molecules CHO Cells Cricetinae Cricetulus Dual acting molecules Human CB2 agonists Humans Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - metabolism Synthesis
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Beschreibung
Zusammenfassung:	[Display omitted] Novel azole compounds were prepared which demonstrated potent hCB2 binding activities with antioxidant activity for a selected compound. These compounds show good selectivity over the hCB1 receptor and are full agonists at the hCB2 receptor.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2014.11.003