Mitigating Effects of Combined Prenatal and Postnatal Exposure to Ethanol on Learned Persistence in the Weanling Rat: A Replication Under High-Peak Conditions

Replicating an earlier report under low-peak blood ethanol concentration (BEC) conditions, weanling rats, exposed in utero or postnatally to levels of ethanol that resulted in high-peak BECs, showed an attenuated partial reinforcement extinction effect, whereas pups exposed both pre- and postnatally...

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Veröffentlicht in:Behavioral neuroscience 1993-12, Vol.107 (6), p.1059-1066
Hauptverfasser: Diaz-Granados, Jaime L, Greene, Paul L, Amsel, Abram
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Sprache:eng
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Zusammenfassung:Replicating an earlier report under low-peak blood ethanol concentration (BEC) conditions, weanling rats, exposed in utero or postnatally to levels of ethanol that resulted in high-peak BECs, showed an attenuated partial reinforcement extinction effect, whereas pups exposed both pre- and postnatally did not differ from controls. Also supporting earlier work, postnatal exposure resulted in significantly reduced brain weight and had effects on hippocampal measures. These results from the combined-exposure group, along with earlier work, point to a possible mitigating influence in the rat of prenatal exposure to ethanol on the behavioral effects of postnatal exposure. They suggest that a protective factor may be operating, akin to the proactive immunoreactive effects of heat shock proteins shown in recent work at the cellular and hippocampal levels.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.107.6.1059