Synthesis of tritium labeled (±) 15-deoxyspergualin trihydrochloride
Tritium labeled (±) 15‐deoxyspergualin, (±)‐7‐[(aminoiminomethyl) amino]‐N‐[2‐[[4‐[(3‐aminopropyl) amino]butyl]amino]‐1‐hydroxy‐2‐oxoethyl][4,5‐3H2]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7‐guanidino[4,5‐3H2] heptanamide hydrochloride and glyoxyloylspermidin...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 1993-02, Vol.33 (2), p.137-145 |
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| container_end_page | 145 |
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| container_issue | 2 |
| container_start_page | 137 |
| container_title | Journal of labelled compounds & radiopharmaceuticals |
| container_volume | 33 |
| creator | Dischino, D. D. Cook, D. J. Saulnier, M. G. Tepper, M. A. |
| description | Tritium labeled (±) 15‐deoxyspergualin, (±)‐7‐[(aminoiminomethyl) amino]‐N‐[2‐[[4‐[(3‐aminopropyl) amino]butyl]amino]‐1‐hydroxy‐2‐oxoethyl][4,5‐3H2]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7‐guanidino[4,5‐3H2] heptanamide hydrochloride and glyoxyloylspermidine dihydrochloride in a total yield of 14.5%. The radiochemical purity was determined to be 91.1% and 95.4% on two different HPLC systems. |
| doi_str_mv | 10.1002/jlcr.2580330208 |
| format | Article |
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D. ; Cook, D. J. ; Saulnier, M. G. ; Tepper, M. A.</creator><creatorcontrib>Dischino, D. D. ; Cook, D. J. ; Saulnier, M. G. ; Tepper, M. A.</creatorcontrib><description>Tritium labeled (±) 15‐deoxyspergualin, (±)‐7‐[(aminoiminomethyl) amino]‐N‐[2‐[[4‐[(3‐aminopropyl) amino]butyl]amino]‐1‐hydroxy‐2‐oxoethyl][4,5‐3H2]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7‐guanidino[4,5‐3H2] heptanamide hydrochloride and glyoxyloylspermidine dihydrochloride in a total yield of 14.5%. The radiochemical purity was determined to be 91.1% and 95.4% on two different HPLC systems.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.2580330208</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>(±) 15-deoxyspergualin ; Aliphatic compounds ; Chemistry ; DSG ; Exact sciences and technology ; immunosuppressive ; Organic chemistry ; Preparations and properties ; Tritium</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 1993-02, Vol.33 (2), p.137-145</ispartof><rights>Copyright © 1993 John Wiley & Sons, Ltd.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3898-d4afbbd9acdf894882b194c04a3dd0f6db8642e646dc42f32f42ae2882159e093</citedby><cites>FETCH-LOGICAL-c3898-d4afbbd9acdf894882b194c04a3dd0f6db8642e646dc42f32f42ae2882159e093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjlcr.2580330208$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjlcr.2580330208$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4553638$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Dischino, D. D.</creatorcontrib><creatorcontrib>Cook, D. J.</creatorcontrib><creatorcontrib>Saulnier, M. G.</creatorcontrib><creatorcontrib>Tepper, M. A.</creatorcontrib><title>Synthesis of tritium labeled (±) 15-deoxyspergualin trihydrochloride</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Label Compd Radiopharm</addtitle><description>Tritium labeled (±) 15‐deoxyspergualin, (±)‐7‐[(aminoiminomethyl) amino]‐N‐[2‐[[4‐[(3‐aminopropyl) amino]butyl]amino]‐1‐hydroxy‐2‐oxoethyl][4,5‐3H2]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7‐guanidino[4,5‐3H2] heptanamide hydrochloride and glyoxyloylspermidine dihydrochloride in a total yield of 14.5%. The radiochemical purity was determined to be 91.1% and 95.4% on two different HPLC systems.</description><subject>(±) 15-deoxyspergualin</subject><subject>Aliphatic compounds</subject><subject>Chemistry</subject><subject>DSG</subject><subject>Exact sciences and technology</subject><subject>immunosuppressive</subject><subject>Organic chemistry</subject><subject>Preparations and properties</subject><subject>Tritium</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOAjEYhRujiYiu3c7CGF0M9DZlJq6UIGoIJuJt13R6kWJhsB0i81i-gk_mEAjGlat_cb7v_MkB4BjBFoIQtydO-hZOUkgIxDDdAQ0EsyxGhNJd0ICE4ZjW4T44CGECYZ1R2gC9UTUrxzrYEBUmKr0t7WIaOZFrp1V09v11HqEkVrpYVmGu_dtCODtbceNK-UKOXeGt0odgzwgX9NHmNsHTde-xexMP7vu33ctBLEmapbGiwuS5yoRUJs1omuIcZVRCKohS0DCVp4xizShTkmJDsKFYaFxzKMk0zEgTnK575774WOhQ8qkNUjsnZrpYBI4YwwQmrAbba1D6IgSvDZ97OxW-4gjy1Vx8NRf_nas2TjbVIkjhjBczacNWo0lCGFlhF2vs0zpd_dfK7wbdhz9P4rVtQ6mXW1v4d846pJPwl2GfD4fdK_w6euaI_AC-noxO</recordid><startdate>199302</startdate><enddate>199302</enddate><creator>Dischino, D. D.</creator><creator>Cook, D. J.</creator><creator>Saulnier, M. G.</creator><creator>Tepper, M. A.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>199302</creationdate><title>Synthesis of tritium labeled (±) 15-deoxyspergualin trihydrochloride</title><author>Dischino, D. D. ; Cook, D. J. ; Saulnier, M. G. ; Tepper, M. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3898-d4afbbd9acdf894882b194c04a3dd0f6db8642e646dc42f32f42ae2882159e093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>(±) 15-deoxyspergualin</topic><topic>Aliphatic compounds</topic><topic>Chemistry</topic><topic>DSG</topic><topic>Exact sciences and technology</topic><topic>immunosuppressive</topic><topic>Organic chemistry</topic><topic>Preparations and properties</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dischino, D. D.</creatorcontrib><creatorcontrib>Cook, D. J.</creatorcontrib><creatorcontrib>Saulnier, M. G.</creatorcontrib><creatorcontrib>Tepper, M. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dischino, D. D.</au><au>Cook, D. J.</au><au>Saulnier, M. G.</au><au>Tepper, M. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of tritium labeled (±) 15-deoxyspergualin trihydrochloride</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Label Compd Radiopharm</addtitle><date>1993-02</date><risdate>1993</risdate><volume>33</volume><issue>2</issue><spage>137</spage><epage>145</epage><pages>137-145</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>Tritium labeled (±) 15‐deoxyspergualin, (±)‐7‐[(aminoiminomethyl) amino]‐N‐[2‐[[4‐[(3‐aminopropyl) amino]butyl]amino]‐1‐hydroxy‐2‐oxoethyl][4,5‐3H2]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7‐guanidino[4,5‐3H2] heptanamide hydrochloride and glyoxyloylspermidine dihydrochloride in a total yield of 14.5%. The radiochemical purity was determined to be 91.1% and 95.4% on two different HPLC systems.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jlcr.2580330208</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0362-4803 |
| ispartof | Journal of labelled compounds & radiopharmaceuticals, 1993-02, Vol.33 (2), p.137-145 |
| issn | 0362-4803 1099-1344 |
| language | eng |
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| source | Wiley Online Library Journals |
| subjects | (±) 15-deoxyspergualin Aliphatic compounds Chemistry DSG Exact sciences and technology immunosuppressive Organic chemistry Preparations and properties Tritium |
| title | Synthesis of tritium labeled (±) 15-deoxyspergualin trihydrochloride |
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