Synthesis of tritium labeled (±) 15-deoxyspergualin trihydrochloride

Synthesis of tritium labeled (±) 15-deoxyspergualin trihydrochloride

Tritium labeled (±) 15‐deoxyspergualin, (±)‐7‐[(aminoiminomethyl) amino]‐N‐[2‐[[4‐[(3‐aminopropyl) amino]butyl]amino]‐1‐hydroxy‐2‐oxoethyl][4,5‐3H2]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7‐guanidino[4,5‐3H2] heptanamide hydrochloride and glyoxyloylspermidin...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1993-02, Vol.33 (2), p.137-145
Hauptverfasser: Dischino, D. D., Cook, D. J., Saulnier, M. G., Tepper, M. A.
Format: Artikel
Sprache:eng
Schlagworte:
(±) 15-deoxyspergualin
Aliphatic compounds
Chemistry
DSG
Exact sciences and technology
immunosuppressive
Organic chemistry
Preparations and properties
Tritium
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Zusammenfassung:Tritium labeled (±) 15‐deoxyspergualin, (±)‐7‐[(aminoiminomethyl) amino]‐N‐[2‐[[4‐[(3‐aminopropyl) amino]butyl]amino]‐1‐hydroxy‐2‐oxoethyl][4,5‐3H2]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7‐guanidino[4,5‐3H2] heptanamide hydrochloride and glyoxyloylspermidine dihydrochloride in a total yield of 14.5%. The radiochemical purity was determined to be 91.1% and 95.4% on two different HPLC systems.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580330208