Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE

Characteristic Hospital-based study Population-based study Case Control Number 1239 447 3361 Responders to questionnaire, n (%) NA NA 3299 (98.2) Age (y) 5.18 ± 3.86 9.32 ± 2.47 8.75 ± 2.90 Sex (M/F) 717/522 231/216 1719/1588 BMI[low *] NA NA 17.89 ± 3.17 Lifetime AD symptoms NA NA 709 of 2349 (23.2%) Parental history of allergic diseases NA NA 1068 of 3056 (34.9%) Parental history of asthma NA NA 117 of 2911 (4.0%) Parental history of AR NA NA 953 of 3033 (31.4%) Parental history of AD NA NA 237 of 2933 (8.1%) Environmental tobacco smoking NA NA 1342 of 3095 (43.4%) Educational level of mother =University graduate NA NA 1797 of 3039 (59.1%) Economic state (monthly income) Low (=5 million won) NA NA 415 of 2977 (13.9%) Mold exposure (visible mold) During infancy NA NA 564 of 2932 (19.2%) During the previous year NA NA 635 of 2930 (21.7%) Biomarker Total IgE (IU/mL) 512.62 ± 1095.99 57.70 ± 124.34 204.08 ± 394.16 Claudin-1 Frequency of rs9290929 A 0.933 0.953 0.946 G 0.067 0.047 0.054 Table E1 Subject characteristics Values are mean ± SD or proportion.AR, Allergic rhinitis; F, female; M, male; NA, not available. Risk factors AD Sx ever[low *] aOR (95% CI)[dagger] P value Demographic factors Sex: male 1.11 (0.91-1.34) .299 BMI 1.03 (0.99-1.06) .142 Age 0.92 (0.89-0.96) =5 million won) 1.05 (0.78-1.41) .747 Maternal education (