Biorefineries for the production of top building block chemicals and their derivatives

Due to the growing concerns on the climate change and sustainability on petrochemical resources, DOE selected and announced the bio-based top 12 building blocks and discussed the needs for developing biorefinery technologies to replace the current petroleum based industry in 2004. Over the last 10 years after its announcement, many studies have been performed for the development of efficient technologies for the bio-based production of these chemicals and derivatives. Now, ten chemicals among these top 12 chemicals, excluding the l-aspartic acid and 3-hydroxybutyrolactone, have already been commercialized or are close to commercialization. In this paper, we review the current status of biorefinery development for the production of these platform chemicals and their derivatives. In addition, current technological advances on industrial strain development for the production of platform chemicals using micro-organisms will be covered in detail with case studies on succinic acid and 3-hydroxypropionic acid as examples. •The status of top 12 chemicals listed in the 2004 DOE report is reviewed.•The status of top 10 chemicals revised in the 2010 report is also reviewed.•Most of these chemicals have been or are being commercialized.•Metabolic engineering is essential for maximizing the strain performance.•The era of bio-based production of chemicals from renewable biomass is coming.