Synthesis of new piroxicam derivatives and their influence on lipid bilayers

A novel series of potentially biologically active 1,2-benzothiazine 1,1-dioxides--analogs of piroxicam (a recognized non-steroidal anti-inflammatory drug) were synthesized from commercially available saccharin. All of the synthesized compounds were subjected to preliminary evaluation for their abili...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2014-11, Vol.71 (6), p.1045-1050
Hauptverfasser:	Szczęśniak-Sięga, Berenika, Maniewska, Jadwiga, Poła, Andrzej, Środa-Pomianek, Kamila, Malinka, Wiesław, Michalak, Krystyna
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Lipid Bilayers - chemistry Models, Molecular Molecular Structure Piroxicam - analogs & derivatives Piroxicam - chemical synthesis Piroxicam - chemistry Piroxicam - pharmacology Spectrometry, Fluorescence
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Zusammenfassung:	A novel series of potentially biologically active 1,2-benzothiazine 1,1-dioxides--analogs of piroxicam (a recognized non-steroidal anti-inflammatory drug) were synthesized from commercially available saccharin. All of the synthesized compounds were subjected to preliminary evaluation for their ability to interact with lipid bilayers. The influence of the new derivatives of piroxicam on liposomes made of EYPC was investigated by fluorescence spectroscopy with two fluorescent probes--Laurdan and Prodan. All the studied compounds showed an interaction with model membranes.
ISSN:	0001-6837