Assessment of Lipophilic vs. Hydrophilic Statin Therapy in Acute Myocardial Infarction: ALPS-AMI Study

Background:Statins reduce the incidence of cardiovascular events, but no randomized trial has investigated the best statins for secondary prevention. We compared the efficacy of hydrophilic pravastatin with that of lipophilic atorvastatin in patients with acute myocardial infarction (AMI).Methods an...

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Veröffentlicht in:	Circulation Journal 2014/12/25, Vol.79(1), pp.161-168
Hauptverfasser:	Izawa, Atsushi, Kashima, Yuichiro, Miura, Takashi, Ebisawa, Soichiro, Kitabayashi, Hiroshi, Yamamoto, Hiroaki, Sakurai, Shunpei, Kagoshima, Mitsuru, Tomita, Takeshi, Miyashita, Yusuke, Koyama, Jun, Ikeda, Uichi, on behalf of the ALPS-AMI Investigators
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myocardial infarction Aged Atorvastatin Calcium - chemistry Atorvastatin Calcium - pharmacokinetics Atorvastatin Calcium - therapeutic use Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Cholesterol - classification Cholesterol, LDL - blood Female Glycated Hemoglobin A - analysis Heart Failure - epidemiology Heart Failure - prevention & control Hospitalization - statistics & numerical data Humans Hydrophobic and Hydrophilic Interactions Hypercholesterolemia - blood Hypercholesterolemia - complications Hypercholesterolemia - drug therapy Japan - epidemiology Kaplan-Meier Estimate Lipids - blood Male Middle Aged Mortality Myocardial Infarction - blood Myocardial Infarction - epidemiology Myocardial Infarction - etiology Myocardial Revascularization - utilization Patient Acceptance of Health Care Pravastatin - chemistry Pravastatin - pharmacokinetics Pravastatin - therapeutic use Recurrence Secondary prevention Single-Blind Method Solubility Statin
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Zusammenfassung:	Background:Statins reduce the incidence of cardiovascular events, but no randomized trial has investigated the best statins for secondary prevention. We compared the efficacy of hydrophilic pravastatin with that of lipophilic atorvastatin in patients with acute myocardial infarction (AMI).Methods and Results:A prospective, multicenter study enrolled 508 patients (410 men; mean age, 66.0±11.6 years) with AMI who were randomly assigned to atorvastatin (n=255) or pravastatin (n=253). The target control level of low-density lipoprotein cholesterol (LDL-C) was
ISSN:	1346-9843 1347-4820
DOI:	10.1253/circj.CJ-14-0877