Use of Proton Pump Inhibitors Is Associated With Anemia in Cardiovascular Outpatients

Background:Proton pump inhibitors (PPI) are frequently prescribed in combination with aspirin for preventing peptic ulcer in patients with atherosclerotic diseases. In contrast, long-term use of PPI has been suggested to be associated with iron or vitamin B12deficiency. The effect of PPI on hemoglob...

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Veröffentlicht in:	Circulation Journal 2014/12/25, Vol.79(1), pp.193-200
Hauptverfasser:	Shikata, Toshiyuki, Sasaki, Naoko, Ueda, Masahiro, Kimura, Takeshi, Itohara, Kanako, Sugahara, Masataka, Fukui, Miho, Manabe, Eri, Masuyama, Tohru, Tsujino, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anemia Anemia - blood Anemia - chemically induced Anemia - etiology Blood Cell Count Body Mass Index Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Creatinine - blood Diabetes Mellitus - epidemiology Erythrocyte Indices Female Hemoglobin Hemoglobins - analysis Humans Hyperlipidemias - epidemiology Hyperuricemia - epidemiology Iron - deficiency Kidney Diseases - blood Kidney Diseases - epidemiology Male Outpatients - statistics & numerical data Peptic Ulcer Hemorrhage - epidemiology Peptic Ulcer Hemorrhage - prevention & control Peripheral Arterial Disease - blood Peripheral Arterial Disease - epidemiology Polypharmacy Proton pump inhibitor Proton Pump Inhibitors - adverse effects Proton Pump Inhibitors - pharmacology Proton Pump Inhibitors - therapeutic use Retrospective Studies Risk Factors Vitamin B Deficiency - blood Vitamin B Deficiency - chemically induced
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Zusammenfassung:	Background:Proton pump inhibitors (PPI) are frequently prescribed in combination with aspirin for preventing peptic ulcer in patients with atherosclerotic diseases. In contrast, long-term use of PPI has been suggested to be associated with iron or vitamin B12deficiency. The effect of PPI on hemoglobin (Hb) concentration, however, has not been clarified in cardiovascular outpatients.Methods and Results:We retrospectively investigated the clinical characteristics of 278 continuous outpatients who received blood test including complete blood count and serum creatinine concentration (mean age, 69.9±10.8 years; male, 68.7%). The frequency of anemia was 51% in patients receiving PPI and 19% in those not receiving PPI (chi-squared test, P
ISSN:	1346-9843 1347-4820
DOI:	10.1253/circj.CJ-14-0582