Effect of N-acetyl-l-cysteine on insulin resistance caused by prolonged free fatty acid elevation

Circulating free fatty acids (FFAs) are elevated in obesity and cause insulin resistance. The objective of the current study was to determine whether the antioxidant N-acetyl-l-cysteine (NAC) prevented hepatic and peripheral insulin resistance caused by prolonged elevation of plasma FFAs. Chronicall...

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Veröffentlicht in:	Journal of endocrinology 2015-04, Vol.225 (1), p.1-7
Hauptverfasser:	Pereira, Sandra, Shah, Anu, George Fantus, I, W Joseph, Jamie, Giacca, Adria
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Biomarkers Blood Glucose Emulsions - administration & dosage Fatty Acids, Nonesterified - blood Female Free Radical Scavengers - pharmacology Glucose - metabolism Heparin - administration & dosage Insulin Resistance - physiology Oxidative Stress - drug effects Oxidative Stress - physiology Phospholipids - administration & dosage Rats Rats, Wistar Soybean Oil - administration & dosage
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Zusammenfassung:	Circulating free fatty acids (FFAs) are elevated in obesity and cause insulin resistance. The objective of the current study was to determine whether the antioxidant N-acetyl-l-cysteine (NAC) prevented hepatic and peripheral insulin resistance caused by prolonged elevation of plasma FFAs. Chronically cannulated Wistar rats received saline (SAL), Intralipid plus heparin (IH), IH plus NAC, or NAC i.v. infusion for 48 h. Insulin sensitivity was determined using the hyperinsulinemic–euglycemic clamp with tritiated glucose tracer. IH induced hepatic and peripheral insulin resistance (P
ISSN:	0022-0795 1479-6805
DOI:	10.1530/JOE-14-0676