Xeroderma pigmentosum complementation group C protein (XPC) expression in basal cell carcinoma

The Xeroderma pigmentosum complementation group C protein (XPC) is a general sensor of damaged DNA. Individuals carrying a mutation in XPC genes exhibit marked photosensitivity and increased occurrence of skin cancers. Little is known about the distribution of XPC protein in basal cell carcinoma (BC...

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Veröffentlicht in:	In vivo (Athens) 2015-01, Vol.29 (1), p.35-38
Hauptverfasser:	Yang, Lien-Chuan, Hsiao, Yu-Ping, Lu, Chun-Te, Huang, Chun-Huang, Chao, Wan-Ru, Lin, Yu-Ting, Su, Hsuan-An, Chang, Shih-Liang, Chung, Jing-Gung
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Carcinoma, Basal Cell - genetics Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gene Expression Humans Immunohistochemistry Male Middle Aged Neoplasm Staging Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology
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Zusammenfassung:	The Xeroderma pigmentosum complementation group C protein (XPC) is a general sensor of damaged DNA. Individuals carrying a mutation in XPC genes exhibit marked photosensitivity and increased occurrence of skin cancers. Little is known about the distribution of XPC protein in basal cell carcinoma (BCC). To determine whether the XPC protein is associated with basal cell carcinoma. In the present study, we investigated the protein expression of XPC by immunohistochemistry in 86 cases of BCC and paired-adjacent normal epidermis. The intensity of nuclear XPC expression was significantly higher in BCC compared to adjacent normal epidermis (p
ISSN:	1791-7549