Micro-computed tomography and histomorphometric analysis of the effects of platelet-rich fibrin on bone regeneration in the rabbit calvarium

Highlights • The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (βTCP). • As methods for investigation we prefered micro-computed tomography (micro-CT), histo...

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Veröffentlicht in:	Archives of oral biology 2015-04, Vol.60 (4), p.606-614
Hauptverfasser:	Acar, Ahmet Hüseyin, Yolcu, Ümit, Gül, Mehmet, Keleş, Ali, Erdem, Necip Fazıl, Altundag Kahraman, Sevil
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Beta-tricalcium phosphate Blood Platelets - physiology Bone Regeneration - drug effects Bone Regeneration - physiology Bone Substitutes - pharmacology Calvarial defect Dentistry Fibrin - pharmacology Hydroxyapatite Hydroxyapatites - pharmacology Platelet-rich fibrin Rabbit Rabbits Skull - diagnostic imaging Skull - surgery X-Ray Microtomography
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Beschreibung
Zusammenfassung:	Highlights • The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (βTCP). • As methods for investigation we prefered micro-computed tomography (micro-CT), histological and histomorphometric analysis. • To conclude, PRF increases new bone formation either alone or in combination with HA/βTCP. • To conclude, HA/βTCP increases new bone formation either alone or in combination with PRF.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2014.09.017