Epicardial and Pericardial Fat in Type 2 Diabetes: Favourable Effects of Biliopancreatic Diversion

Purpose Ectopic fat is often identified in obese subjects who are susceptible to the development of type 2 diabetes mellitus (T2DM). The ectopic fat favours the decrease in insulin sensitivity (IS) and adiponectin levels. We aimed to evaluate the effect of biliopancreatic diversion (BPD) on the accu...

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Veröffentlicht in:Obesity surgery 2015-03, Vol.25 (3), p.477-485
Hauptverfasser: Vasques, Ana Carolina Junqueira, Pareja, José Carlos, Souza, José Roberto Mattos, Yamanaka, Ademar, de Oliveira, Maria da Saúde, Novaes, Fernanda Satake, Chaim, Élinton Adami, Piccinini, Francesca, Dalla Man, Chiara, Cobelli, Claudio, Geloneze, Bruno
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Sprache:eng
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Zusammenfassung:Purpose Ectopic fat is often identified in obese subjects who are susceptible to the development of type 2 diabetes mellitus (T2DM). The ectopic fat favours the decrease in insulin sensitivity (IS) and adiponectin levels. We aimed to evaluate the effect of biliopancreatic diversion (BPD) on the accumulation of ectopic fat, adiponectin levels and IS in obese with T2DM. Materials and Methods A nonrandomised controlled study was performed on sixty-eight women: 19 lean-control (23.0 ± 2.2 kg/m 2 ) and 18 obese-control (35.0 ± 4.8 kg/m 2 ) with normal glucose tolerance and 31 obese with T2DM (36.3 ± 3.7 kg/m 2 ). Of the 31 diabetic women, 20 underwent BPD and were reassessed 1 month and 12 months after surgery. The subcutaneous adipose tissue, visceral adipose tissue, epicardial adipose tissue and pericardial adipose tissue were evaluated by ultrasonography. The IS was assessed by a hyperglycaemic clamp, applying the minimal model of glucose. Results One month after surgery, there was a reduction in visceral and subcutaneous adipose tissues, whereas epicardial and pericardial adipose tissues exhibited significant reduction at the 12-month assessment ( p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-014-1400-1