Identification and synthesis of a unique disulfide dimeric metabolite of primisulfuron-methyl in the mouse

The major metabolic pathway for primisulfuron-methyl in animals involves hydroxylation of the pyrimidine ring followed by conjugation. This investigation found a unique metabolite in mice fed at high feeding levels ( 5000 ppm) of the compound. The unique metabolite is identified as a disulfide dimer...

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Veröffentlicht in:	Journal of agricultural and food chemistry 1993-12, Vol.41 (12), p.2411-2415
Hauptverfasser:	Caps, Thomas M, Heard, Nina E, Simmons, Dana P, Connor, Connie L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences HERBICIDAS HERBICIDE Medical sciences METABOLISME METABOLISMO METABOLITE METABOLITOS Pesticides, fertilizers and other agrochemicals toxicology RATON SOURIS Toxicology
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container_title	Journal of agricultural and food chemistry
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creator	Caps, Thomas M Heard, Nina E Simmons, Dana P Connor, Connie L
description	The major metabolic pathway for primisulfuron-methyl in animals involves hydroxylation of the pyrimidine ring followed by conjugation. This investigation found a unique metabolite in mice fed at high feeding levels ( 5000 ppm) of the compound. The unique metabolite is identified as a disulfide dimer of the parent compound, and its synthesis is reported
doi_str_mv	10.1021/jf00036a037
format	Article
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Agric. Food Chem</addtitle><description>The major metabolic pathway for primisulfuron-methyl in animals involves hydroxylation of the pyrimidine ring followed by conjugation. This investigation found a unique metabolite in mice fed at high feeding levels ( 5000 ppm) of the compound. 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subjects	Biological and medical sciences HERBICIDAS HERBICIDE Medical sciences METABOLISME METABOLISMO METABOLITE METABOLITOS Pesticides, fertilizers and other agrochemicals toxicology RATON SOURIS Toxicology
title	Identification and synthesis of a unique disulfide dimeric metabolite of primisulfuron-methyl in the mouse
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