Identification and synthesis of a unique disulfide dimeric metabolite of primisulfuron-methyl in the mouse

Identification and synthesis of a unique disulfide dimeric metabolite of primisulfuron-methyl in the mouse

The major metabolic pathway for primisulfuron-methyl in animals involves hydroxylation of the pyrimidine ring followed by conjugation. This investigation found a unique metabolite in mice fed at high feeding levels ( 5000 ppm) of the compound. The unique metabolite is identified as a disulfide dimer...

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Veröffentlicht in:Journal of agricultural and food chemistry 1993-12, Vol.41 (12), p.2411-2415
Hauptverfasser: Caps, Thomas M, Heard, Nina E, Simmons, Dana P, Connor, Connie L
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
HERBICIDAS
HERBICIDE
Medical sciences
METABOLISME
METABOLISMO
METABOLITE
METABOLITOS
Pesticides, fertilizers and other agrochemicals toxicology
RATON
SOURIS
Toxicology
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Zusammenfassung:The major metabolic pathway for primisulfuron-methyl in animals involves hydroxylation of the pyrimidine ring followed by conjugation. This investigation found a unique metabolite in mice fed at high feeding levels ( 5000 ppm) of the compound. The unique metabolite is identified as a disulfide dimer of the parent compound, and its synthesis is reported
ISSN:0021-8561
1520-5118
DOI:10.1021/jf00036a037