Hepatoprotective Sesquiterpenes and Rutinosides from Murraya koenigii (L.) Spreng

Three new sesquiterpenes (1–3) and two new rutinosides (4 and 5) along with 17 known compounds (6–22) were isolated from the leaves of Murraya koenigii (L.) Spreng. The new compounds were elucidated as (3R,5S,6R)-3,5,6-trihydroxy-1,1,5-trimethylcyclohexyl-8-butyn-9-one (1), (8E,9R)-ethyl-7-(3S,5R,6S)-3,6-dihydroxy-1,1,5-trimethylcyclohexyl-9-hydroxybut-8-enoate (2), (3R)-3-O-β-d-glucoside-6′-d-apiose-β-ionone (3), 4-O-β-d-rutinosyl-3-methoxyphenyl-1-propanone (4), and 1-O-β-d-rutinosyl-2(R)-ethyl-1-pentanol (5) based on their spectroscopic data. Compounds 1, 4, 5, 18, and 21 (10 μM) exhibited moderate hepatoprotective activities.