Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis

Abstract The future of genetic diagnostics will see a move toward massively parallel next-generation sequencing of a patient's DNA. Amyotrophic lateral sclerosis (ALS) is one of the diseases that would benefit from this prospect. Exploring this idea, we designed a screening panel to sequence 25...

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Veröffentlicht in:	Neurobiology of aging 2015-03, Vol.36 (3), p.1600.e5-1600.e8
Hauptverfasser:	Morgan, Sarah, Shoai, Maryam, Fratta, Pietro, Sidle, Katie, Orrell, Richard, Sweeney, Mary G, Shatunov, Aleksey, Sproviero, William, Jones, Ashley, Al-Chalabi, Ammar, Malaspina, Andrea, Houlden, Henry, Hardy, John, Pittman, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	ALS Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - diagnosis Amyotrophic Lateral Sclerosis - genetics Cohort Studies Diagnosis Genetic High-Throughput Nucleotide Sequencing - economics High-Throughput Nucleotide Sequencing - methods High-Throughput Nucleotide Sequencing - trends Humans Internal Medicine MiSeq Neurogenetics Neurology Next-generation sequencing NGS Polymorphism, Genetic - genetics Reproducibility of Results Sequencing
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