Cardiovascular and behavioral effects produced by administration of liposome-entrapped GABA into the rat central nervous system

Highlights • Liposomes are nanosystems that allow a sustained release of entrapped substances. • GABA is the most prevalent inhibitory neurotransmitter of the central nervous system. • We developed and tested a liposomal formulation of GABA for application in CNS. • GABA-liposomes are a potential to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-01, Vol.285, p.60-69
Hauptverfasser:	Vaz, G.C, Bahia, A.P.C.O, de Figueiredo Müller-Ribeiro, F.C, Xavier, C.H, Patel, K.P, Santos, R.A.S, Moreira, F.A, Frézard, F, Fontes, M.A.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - drug therapy Anxiety - physiopathology Arterial Pressure - drug effects behavior Bicuculline - administration & dosage Bicuculline - analogs & derivatives cardiovascular Cardiovascular Agents - administration & dosage Catheters, Indwelling Central Nervous System Agents - administration & dosage Exploratory Behavior - drug effects Exploratory Behavior - physiology GABA GABA Agents - administration & dosage gamma-Aminobutyric Acid - administration & dosage Heart Rate - drug effects Infusions, Intraventricular Kidney - innervation liposomes Liposomes - administration & dosage Male Microinjections Neurology Rats, Wistar Stress, Physiological - drug effects Stress, Physiological - physiology Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Tachycardia - drug therapy Tachycardia - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Liposomes are nanosystems that allow a sustained release of entrapped substances. • GABA is the most prevalent inhibitory neurotransmitter of the central nervous system. • We developed and tested a liposomal formulation of GABA for application in CNS. • GABA-liposomes are a potential tool for studies on the central nervous system.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.10.067