44. Rapid induction of apoptosis at ultra low temperatures enhances the efficacy of prostate cancer cryoablation

Investigations into the molecular-based responses of prostate cancer following cold exposure have led to the discovery of delayed-onset, apoptotic cell death within the periphery of cryolesions. The apoptotic pathway typically attributed to this delayed death is the intrinsic/mitochondrial-mediated pathway characterized by a loss of mitochondrial potential, release of cytochrome c, and activation of caspase-9. Recent studies, however, have shown that at lower temperatures within the core of the cryogenic lesion (