Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration
[Display omitted] •Riparin A reduces carrageenan-induced adhesion and rolling of leukocytes.•Riparin A reduces inflammatory response by inhibiting vascular and cellular events.•Riparin A is safe to gastric mucosa as compared with indomethacin.•Riparin A reduced the production of proinflammatory cyto...
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creator | Silva, Renan O. Damasceno, Samara R.B. Silva, Irismara S. Silva, Valdelânia G. Brito, Camila F.C. Teixeira, Antônio Éder A. Nunes, Geandra B.L. Camara, Celso A. Filho, José Maria B. Gutierrez, Stanley J.C. Ribeiro, Ronaldo A. Souza, Marcellus H.L.P. Barbosa, André L.R. Freitas, Rivelilson M. Medeiros, Jand Venes R. |
description | [Display omitted]
•Riparin A reduces carrageenan-induced adhesion and rolling of leukocytes.•Riparin A reduces inflammatory response by inhibiting vascular and cellular events.•Riparin A is safe to gastric mucosa as compared with indomethacin.•Riparin A reduced the production of proinflammatory cytokines.
Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress. |
doi_str_mv | 10.1016/j.cbi.2015.01.029 |
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•Riparin A reduces carrageenan-induced adhesion and rolling of leukocytes.•Riparin A reduces inflammatory response by inhibiting vascular and cellular events.•Riparin A is safe to gastric mucosa as compared with indomethacin.•Riparin A reduced the production of proinflammatory cytokines.
Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.</description><identifier>ISSN: 0009-2797</identifier><identifier>EISSN: 1872-7786</identifier><identifier>DOI: 10.1016/j.cbi.2015.01.029</identifier><identifier>PMID: 25656915</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - therapeutic use ; Antioxidants - isolation & purification ; Antioxidants - therapeutic use ; Benzamides - isolation & purification ; Benzamides - therapeutic use ; Carrageenan - adverse effects ; Carrageenan - immunology ; Cell Adhesion - drug effects ; Cytokines - immunology ; Edema - chemically induced ; Edema - drug therapy ; Edema - immunology ; Edema - pathology ; Extremities - pathology ; Immune System Diseases - chemically induced ; Immune System Diseases - drug therapy ; Immune System Diseases - immunology ; Immune System Diseases - pathology ; Inflammation ; Inflammation - chemically induced ; Inflammation - drug therapy ; Inflammation - immunology ; Inflammation - pathology ; Lauraceae - chemistry ; Leukocyte Disorders - chemically induced ; Leukocyte Disorders - drug therapy ; Leukocyte Disorders - immunology ; Leukocyte Disorders - pathology ; Leukocyte Rolling - drug effects ; Male ; Mice ; Neutrophil ; Neutrophils - drug effects ; Neutrophils - immunology ; Neutrophils - pathology ; Oxidative stress ; Oxidative Stress - drug effects ; Peritonitis - chemically induced ; Peritonitis - drug therapy ; Peritonitis - immunology ; Peritonitis - pathology ; Peroxidase - immunology ; Phenethylamines - isolation & purification ; Phenethylamines - therapeutic use ; Riparin</subject><ispartof>Chemico-biological interactions, 2015-03, Vol.229, p.55-63</ispartof><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1267d0a7e9c96080d1b0c66229efc883ad84720f70a16700fb1d3f2f6e5761243</citedby><cites>FETCH-LOGICAL-c353t-1267d0a7e9c96080d1b0c66229efc883ad84720f70a16700fb1d3f2f6e5761243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009279715000538$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25656915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Renan O.</creatorcontrib><creatorcontrib>Damasceno, Samara R.B.</creatorcontrib><creatorcontrib>Silva, Irismara S.</creatorcontrib><creatorcontrib>Silva, Valdelânia G.</creatorcontrib><creatorcontrib>Brito, Camila F.C.</creatorcontrib><creatorcontrib>Teixeira, Antônio Éder A.</creatorcontrib><creatorcontrib>Nunes, Geandra B.L.</creatorcontrib><creatorcontrib>Camara, Celso A.</creatorcontrib><creatorcontrib>Filho, José Maria B.</creatorcontrib><creatorcontrib>Gutierrez, Stanley J.C.</creatorcontrib><creatorcontrib>Ribeiro, Ronaldo A.</creatorcontrib><creatorcontrib>Souza, Marcellus H.L.P.</creatorcontrib><creatorcontrib>Barbosa, André L.R.</creatorcontrib><creatorcontrib>Freitas, Rivelilson M.</creatorcontrib><creatorcontrib>Medeiros, Jand Venes R.</creatorcontrib><title>Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration</title><title>Chemico-biological interactions</title><addtitle>Chem Biol Interact</addtitle><description>[Display omitted]
•Riparin A reduces carrageenan-induced adhesion and rolling of leukocytes.•Riparin A reduces inflammatory response by inhibiting vascular and cellular events.•Riparin A is safe to gastric mucosa as compared with indomethacin.•Riparin A reduced the production of proinflammatory cytokines.
Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - therapeutic use</subject><subject>Benzamides - isolation & purification</subject><subject>Benzamides - therapeutic use</subject><subject>Carrageenan - adverse effects</subject><subject>Carrageenan - immunology</subject><subject>Cell Adhesion - drug effects</subject><subject>Cytokines - immunology</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>Edema - immunology</subject><subject>Edema - pathology</subject><subject>Extremities - pathology</subject><subject>Immune System Diseases - chemically induced</subject><subject>Immune System Diseases - drug therapy</subject><subject>Immune System Diseases - immunology</subject><subject>Immune System Diseases - pathology</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - immunology</subject><subject>Inflammation - pathology</subject><subject>Lauraceae - chemistry</subject><subject>Leukocyte Disorders - chemically induced</subject><subject>Leukocyte Disorders - drug therapy</subject><subject>Leukocyte Disorders - immunology</subject><subject>Leukocyte Disorders - pathology</subject><subject>Leukocyte Rolling - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Neutrophil</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - pathology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Peritonitis - chemically induced</subject><subject>Peritonitis - drug therapy</subject><subject>Peritonitis - immunology</subject><subject>Peritonitis - pathology</subject><subject>Peroxidase - immunology</subject><subject>Phenethylamines - isolation & purification</subject><subject>Phenethylamines - therapeutic use</subject><subject>Riparin</subject><issn>0009-2797</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EarelD8AF-ciBpGMnsRNxWlVAkSpVQnC2HHtMvUrsYDuV9u1Ju4Ujp9HMfPNL8xHyjkHNgInrQ21GX3NgXQ2sBj68IjvWS15J2YvXZAcAQ8XlIM_JRc6HrQXewhk5553oxMC6Hcnf_aKTD3T_kWpq4rzENVjqUpzpPvhR0_QM6G1dCoZVF6TlAakPbtLzrEtMR5owLzFkpOORztGuky4-BhodDbiWFJcHP9HZ_0rP87fkjdNTxquXekl-fvn84-a2urv_-u1mf1eZpmtKxbiQFrTEwQwCerBsBCME5wM60_eNtn0rOTgJmgkJ4EZmG8edwE4Kxtvmknw45S4p_l4xFzX7bHCadMC4ZsWEgJa1smEbyk6oSTHnhE4tyc86HRUD9eRaHdTmWj25VsDU5nq7ef8Sv44z2n8Xf-VuwKcTgNuTjx6TysZjMGh9QlOUjf4_8X8A64yPuQ</recordid><startdate>20150305</startdate><enddate>20150305</enddate><creator>Silva, Renan O.</creator><creator>Damasceno, Samara R.B.</creator><creator>Silva, Irismara S.</creator><creator>Silva, Valdelânia G.</creator><creator>Brito, Camila F.C.</creator><creator>Teixeira, Antônio Éder A.</creator><creator>Nunes, Geandra B.L.</creator><creator>Camara, Celso A.</creator><creator>Filho, José Maria B.</creator><creator>Gutierrez, Stanley J.C.</creator><creator>Ribeiro, Ronaldo A.</creator><creator>Souza, Marcellus H.L.P.</creator><creator>Barbosa, André L.R.</creator><creator>Freitas, Rivelilson M.</creator><creator>Medeiros, Jand Venes R.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150305</creationdate><title>Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration</title><author>Silva, Renan O. ; Damasceno, Samara R.B. ; Silva, Irismara S. ; Silva, Valdelânia G. ; Brito, Camila F.C. ; Teixeira, Antônio Éder A. ; Nunes, Geandra B.L. ; Camara, Celso A. ; Filho, José Maria B. ; Gutierrez, Stanley J.C. ; Ribeiro, Ronaldo A. ; Souza, Marcellus H.L.P. ; Barbosa, André L.R. ; Freitas, Rivelilson M. ; Medeiros, Jand Venes R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1267d0a7e9c96080d1b0c66229efc883ad84720f70a16700fb1d3f2f6e5761243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - therapeutic use</topic><topic>Benzamides - isolation & purification</topic><topic>Benzamides - therapeutic use</topic><topic>Carrageenan - adverse effects</topic><topic>Carrageenan - immunology</topic><topic>Cell Adhesion - drug effects</topic><topic>Cytokines - immunology</topic><topic>Edema - chemically induced</topic><topic>Edema - drug therapy</topic><topic>Edema - immunology</topic><topic>Edema - pathology</topic><topic>Extremities - pathology</topic><topic>Immune System Diseases - chemically induced</topic><topic>Immune System Diseases - drug therapy</topic><topic>Immune System Diseases - immunology</topic><topic>Immune System Diseases - pathology</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - immunology</topic><topic>Inflammation - pathology</topic><topic>Lauraceae - chemistry</topic><topic>Leukocyte Disorders - chemically induced</topic><topic>Leukocyte Disorders - drug therapy</topic><topic>Leukocyte Disorders - immunology</topic><topic>Leukocyte Disorders - pathology</topic><topic>Leukocyte Rolling - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Neutrophil</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - pathology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Peritonitis - chemically induced</topic><topic>Peritonitis - drug therapy</topic><topic>Peritonitis - immunology</topic><topic>Peritonitis - pathology</topic><topic>Peroxidase - immunology</topic><topic>Phenethylamines - isolation & purification</topic><topic>Phenethylamines - therapeutic use</topic><topic>Riparin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Renan O.</creatorcontrib><creatorcontrib>Damasceno, Samara R.B.</creatorcontrib><creatorcontrib>Silva, Irismara S.</creatorcontrib><creatorcontrib>Silva, Valdelânia G.</creatorcontrib><creatorcontrib>Brito, Camila F.C.</creatorcontrib><creatorcontrib>Teixeira, Antônio Éder A.</creatorcontrib><creatorcontrib>Nunes, Geandra B.L.</creatorcontrib><creatorcontrib>Camara, Celso A.</creatorcontrib><creatorcontrib>Filho, José Maria B.</creatorcontrib><creatorcontrib>Gutierrez, Stanley J.C.</creatorcontrib><creatorcontrib>Ribeiro, Ronaldo A.</creatorcontrib><creatorcontrib>Souza, Marcellus H.L.P.</creatorcontrib><creatorcontrib>Barbosa, André L.R.</creatorcontrib><creatorcontrib>Freitas, Rivelilson M.</creatorcontrib><creatorcontrib>Medeiros, Jand Venes R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Renan O.</au><au>Damasceno, Samara R.B.</au><au>Silva, Irismara S.</au><au>Silva, Valdelânia G.</au><au>Brito, Camila F.C.</au><au>Teixeira, Antônio Éder A.</au><au>Nunes, Geandra B.L.</au><au>Camara, Celso A.</au><au>Filho, José Maria B.</au><au>Gutierrez, Stanley J.C.</au><au>Ribeiro, Ronaldo A.</au><au>Souza, Marcellus H.L.P.</au><au>Barbosa, André L.R.</au><au>Freitas, Rivelilson M.</au><au>Medeiros, Jand Venes R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration</atitle><jtitle>Chemico-biological interactions</jtitle><addtitle>Chem Biol Interact</addtitle><date>2015-03-05</date><risdate>2015</risdate><volume>229</volume><spage>55</spage><epage>63</epage><pages>55-63</pages><issn>0009-2797</issn><eissn>1872-7786</eissn><abstract>[Display omitted]
•Riparin A reduces carrageenan-induced adhesion and rolling of leukocytes.•Riparin A reduces inflammatory response by inhibiting vascular and cellular events.•Riparin A is safe to gastric mucosa as compared with indomethacin.•Riparin A reduced the production of proinflammatory cytokines.
Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25656915</pmid><doi>10.1016/j.cbi.2015.01.029</doi><tpages>9</tpages></addata></record> |
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subjects | Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - therapeutic use Antioxidants - isolation & purification Antioxidants - therapeutic use Benzamides - isolation & purification Benzamides - therapeutic use Carrageenan - adverse effects Carrageenan - immunology Cell Adhesion - drug effects Cytokines - immunology Edema - chemically induced Edema - drug therapy Edema - immunology Edema - pathology Extremities - pathology Immune System Diseases - chemically induced Immune System Diseases - drug therapy Immune System Diseases - immunology Immune System Diseases - pathology Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - immunology Inflammation - pathology Lauraceae - chemistry Leukocyte Disorders - chemically induced Leukocyte Disorders - drug therapy Leukocyte Disorders - immunology Leukocyte Disorders - pathology Leukocyte Rolling - drug effects Male Mice Neutrophil Neutrophils - drug effects Neutrophils - immunology Neutrophils - pathology Oxidative stress Oxidative Stress - drug effects Peritonitis - chemically induced Peritonitis - drug therapy Peritonitis - immunology Peritonitis - pathology Peroxidase - immunology Phenethylamines - isolation & purification Phenethylamines - therapeutic use Riparin |
title | Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration |
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