Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration

[Display omitted] •Riparin A reduces carrageenan-induced adhesion and rolling of leukocytes.•Riparin A reduces inflammatory response by inhibiting vascular and cellular events.•Riparin A is safe to gastric mucosa as compared with indomethacin.•Riparin A reduced the production of proinflammatory cyto...

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Veröffentlicht in:Chemico-biological interactions 2015-03, Vol.229, p.55-63
Hauptverfasser: Silva, Renan O., Damasceno, Samara R.B., Silva, Irismara S., Silva, Valdelânia G., Brito, Camila F.C., Teixeira, Antônio Éder A., Nunes, Geandra B.L., Camara, Celso A., Filho, José Maria B., Gutierrez, Stanley J.C., Ribeiro, Ronaldo A., Souza, Marcellus H.L.P., Barbosa, André L.R., Freitas, Rivelilson M., Medeiros, Jand Venes R.
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container_end_page 63
container_issue
container_start_page 55
container_title Chemico-biological interactions
container_volume 229
creator Silva, Renan O.
Damasceno, Samara R.B.
Silva, Irismara S.
Silva, Valdelânia G.
Brito, Camila F.C.
Teixeira, Antônio Éder A.
Nunes, Geandra B.L.
Camara, Celso A.
Filho, José Maria B.
Gutierrez, Stanley J.C.
Ribeiro, Ronaldo A.
Souza, Marcellus H.L.P.
Barbosa, André L.R.
Freitas, Rivelilson M.
Medeiros, Jand Venes R.
description [Display omitted] •Riparin A reduces carrageenan-induced adhesion and rolling of leukocytes.•Riparin A reduces inflammatory response by inhibiting vascular and cellular events.•Riparin A is safe to gastric mucosa as compared with indomethacin.•Riparin A reduced the production of proinflammatory cytokines. Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.
doi_str_mv 10.1016/j.cbi.2015.01.029
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Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. 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Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - isolation &amp; purification</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antioxidants - isolation &amp; purification</subject><subject>Antioxidants - therapeutic use</subject><subject>Benzamides - isolation &amp; purification</subject><subject>Benzamides - therapeutic use</subject><subject>Carrageenan - adverse effects</subject><subject>Carrageenan - immunology</subject><subject>Cell Adhesion - drug effects</subject><subject>Cytokines - immunology</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>Edema - immunology</subject><subject>Edema - pathology</subject><subject>Extremities - pathology</subject><subject>Immune System Diseases - chemically induced</subject><subject>Immune System Diseases - drug therapy</subject><subject>Immune System Diseases - immunology</subject><subject>Immune System Diseases - pathology</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - immunology</subject><subject>Inflammation - pathology</subject><subject>Lauraceae - chemistry</subject><subject>Leukocyte Disorders - chemically induced</subject><subject>Leukocyte Disorders - drug therapy</subject><subject>Leukocyte Disorders - immunology</subject><subject>Leukocyte Disorders - pathology</subject><subject>Leukocyte Rolling - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Neutrophil</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - pathology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Peritonitis - chemically induced</subject><subject>Peritonitis - drug therapy</subject><subject>Peritonitis - immunology</subject><subject>Peritonitis - pathology</subject><subject>Peroxidase - immunology</subject><subject>Phenethylamines - isolation &amp; 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purification</topic><topic>Phenethylamines - therapeutic use</topic><topic>Riparin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Renan O.</creatorcontrib><creatorcontrib>Damasceno, Samara R.B.</creatorcontrib><creatorcontrib>Silva, Irismara S.</creatorcontrib><creatorcontrib>Silva, Valdelânia G.</creatorcontrib><creatorcontrib>Brito, Camila F.C.</creatorcontrib><creatorcontrib>Teixeira, Antônio Éder A.</creatorcontrib><creatorcontrib>Nunes, Geandra B.L.</creatorcontrib><creatorcontrib>Camara, Celso A.</creatorcontrib><creatorcontrib>Filho, José Maria B.</creatorcontrib><creatorcontrib>Gutierrez, Stanley J.C.</creatorcontrib><creatorcontrib>Ribeiro, Ronaldo A.</creatorcontrib><creatorcontrib>Souza, Marcellus H.L.P.</creatorcontrib><creatorcontrib>Barbosa, André L.R.</creatorcontrib><creatorcontrib>Freitas, Rivelilson M.</creatorcontrib><creatorcontrib>Medeiros, Jand Venes R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Renan O.</au><au>Damasceno, Samara R.B.</au><au>Silva, Irismara S.</au><au>Silva, Valdelânia G.</au><au>Brito, Camila F.C.</au><au>Teixeira, Antônio Éder A.</au><au>Nunes, Geandra B.L.</au><au>Camara, Celso A.</au><au>Filho, José Maria B.</au><au>Gutierrez, Stanley J.C.</au><au>Ribeiro, Ronaldo A.</au><au>Souza, Marcellus H.L.P.</au><au>Barbosa, André L.R.</au><au>Freitas, Rivelilson M.</au><au>Medeiros, Jand Venes R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration</atitle><jtitle>Chemico-biological interactions</jtitle><addtitle>Chem Biol Interact</addtitle><date>2015-03-05</date><risdate>2015</risdate><volume>229</volume><spage>55</spage><epage>63</epage><pages>55-63</pages><issn>0009-2797</issn><eissn>1872-7786</eissn><abstract>[Display omitted] •Riparin A reduces carrageenan-induced adhesion and rolling of leukocytes.•Riparin A reduces inflammatory response by inhibiting vascular and cellular events.•Riparin A is safe to gastric mucosa as compared with indomethacin.•Riparin A reduced the production of proinflammatory cytokines. Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1β) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25656915</pmid><doi>10.1016/j.cbi.2015.01.029</doi><tpages>9</tpages></addata></record>
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ispartof Chemico-biological interactions, 2015-03, Vol.229, p.55-63
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subjects Animals
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - therapeutic use
Antioxidants - isolation & purification
Antioxidants - therapeutic use
Benzamides - isolation & purification
Benzamides - therapeutic use
Carrageenan - adverse effects
Carrageenan - immunology
Cell Adhesion - drug effects
Cytokines - immunology
Edema - chemically induced
Edema - drug therapy
Edema - immunology
Edema - pathology
Extremities - pathology
Immune System Diseases - chemically induced
Immune System Diseases - drug therapy
Immune System Diseases - immunology
Immune System Diseases - pathology
Inflammation
Inflammation - chemically induced
Inflammation - drug therapy
Inflammation - immunology
Inflammation - pathology
Lauraceae - chemistry
Leukocyte Disorders - chemically induced
Leukocyte Disorders - drug therapy
Leukocyte Disorders - immunology
Leukocyte Disorders - pathology
Leukocyte Rolling - drug effects
Male
Mice
Neutrophil
Neutrophils - drug effects
Neutrophils - immunology
Neutrophils - pathology
Oxidative stress
Oxidative Stress - drug effects
Peritonitis - chemically induced
Peritonitis - drug therapy
Peritonitis - immunology
Peritonitis - pathology
Peroxidase - immunology
Phenethylamines - isolation & purification
Phenethylamines - therapeutic use
Riparin
title Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration
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