Quadrivalent meningococcal (MenACWY-TT) conjugate vaccine or a fourth dose of H. influenzae–N. meningitidis C/Y conjugate vaccine (HibMenCY-TT) is immunogenic in toddlers who previously received three doses of HibMenCY-TT in infancy

Highlights • MenACWY-TT (+/− DTaP) was investigated in HibMenCY-TT-primed toddlers. • Prior to booster, 89.9%/96.3% of HibMenCY-primed toddlers had hSBA ≥1:8 for C/Y. • Post-booster 100% of toddlers had hSBA ≥1:8 for MenC/Y and ≥96.1% for MenA/W. • 3 HibMenCY-TT doses prime for MenC/Y with persisten...

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Veröffentlicht in:	Vaccine 2015-02, Vol.33 (7), p.933-941
Hauptverfasser:	Leonardi, Michael, Latiolais, Thomas, Sarpong, Kwabena, Simon, Michael, Twiggs, Jerry, Lei, Paul, Rinderknecht, Stephen, Blatter, Mark, Bianco, Veronique, Baine, Yaela, Friedland, Leonard R, Miller, Jacqueline M
Format:	Artikel
Sprache:	eng
Schlagworte:	ACWY Allergy and Immunology Conjugate vaccine Drug Administration Schedule Female Haemophilus Vaccines - administration & dosage Haemophilus Vaccines - immunology HibMenCY Humans Infant Male Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - immunology Neisseria meningitidis Quadrivalent meningococcal vaccine Serum bactericidal activity Tetanus Toxoid - administration & dosage Tetanus Toxoid - immunology Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - immunology
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Zusammenfassung:	Highlights • MenACWY-TT (+/− DTaP) was investigated in HibMenCY-TT-primed toddlers. • Prior to booster, 89.9%/96.3% of HibMenCY-primed toddlers had hSBA ≥1:8 for C/Y. • Post-booster 100% of toddlers had hSBA ≥1:8 for MenC/Y and ≥96.1% for MenA/W. • 3 HibMenCY-TT doses prime for MenC/Y with persistence until the scheduled booster. • HibMenCY-TT-primed toddlers could be boosted with MenACWY-TT.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.08.027