The internalization and lysosomal degradation of brain AQP4 after ischemic injury

Abstract The membrane-bound water channel aquaporin-4 (AQP4) plays a significant role in maintaining brain water homeostasis. In ischemic brain, changes in the expression level of AQP4 have been reported. Previous studies suggest that the internalization of several membrane-bound proteins, including...

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Veröffentlicht in:	Brain research 2013-11, Vol.1539, p.61-72
Hauptverfasser:	Huang, Juan, Sun, Shan Quan, Lu, Wei Tian, Xu, Jin, Gan, Sheng Wei, Chen, Zhen, Qiu, Guo Ping, Huang, Si Qin, Zhuo, Fei, Liu, Qian, Xu, Shi Ye
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaporin 4 - metabolism Aquaporin-4 Biological and medical sciences Blood-Brain Barrier - pathology brain Brain - drug effects Brain - metabolism Brain - ultrastructure Brain Ischemia - metabolism Brain Ischemia - pathology Cerebral ischemia edema Endosome Female fluorescent antibody technique homeostasis Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Internalization Lysosome lysosomes Lysosomes - metabolism Male Medical sciences Neurology protein kinase C proteins Rats Rats, Sprague-Dawley Tetradecanoylphorbol Acetate - analogs & derivatives Tetradecanoylphorbol Acetate - pharmacology Vascular diseases and vascular malformations of the nervous system
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