Immunogenicity and reactogenicity of Infanrix ™ when co-administered with meningococcal MenACWY-TT conjugate vaccine in toddlers primed with MenHibrix ™ and Pediarix

Highlights • Infanrix + MenACWY-TT was investigated in MenHibrix -primed toddlers. • Infanrix + MenACWY-TT was non-inferior to Infanrix alone except for anti-PT/PRN GMCs. • Pertussis GMCs were higher than in infants in whom Infanrix efficacy was shown. • Reactogenicity of co-administered MenACWY-TT...

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Veröffentlicht in:	Vaccine 2015-02, Vol.33 (7), p.924-932
Hauptverfasser:	Leonardi, Michael, Latiolais, Thomas, Sarpong, Kwabena, Simon, Michael, Twiggs, Jerry, Lei, Paul, Rinderknecht, Stephen, Blatter, Mark, Bianco, Veronique, Baine, Yaela, Friedland, Leonard R, Baccarini, Carmen, Miller, Jacqueline M
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Co-administration Diphtheria-Tetanus-acellular Pertussis Vaccines - adverse effects Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology Diphtheria-Tetanus-Pertussis Vaccine - immunology Drug Administration Schedule DTaP vaccine Female Haemophilus influenzae Haemophilus Vaccines - immunology Hepatitis B Vaccines - immunology HibMenCY-TT Humans Infant Infant, Newborn Male MenACWY-TT Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - immunology Neisseria meningitidis Poliovirus Poliovirus Vaccine, Inactivated - immunology Quadrivalent meningococcal vaccine Tetanus Toxoid - immunology Vaccines, Conjugate - immunology
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Beschreibung
Zusammenfassung:	Highlights • Infanrix + MenACWY-TT was investigated in MenHibrix -primed toddlers. • Infanrix + MenACWY-TT was non-inferior to Infanrix alone except for anti-PT/PRN GMCs. • Pertussis GMCs were higher than in infants in whom Infanrix efficacy was shown. • Reactogenicity of co-administered MenACWY-TT + Infanrix was similar to Infanrix alone. • MenHibrix -primed toddlers could be boosted with MenACWY-TT + Infanrix.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.09.064