Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide
We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadrupl...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2015-02, Vol.13 (7), p.2022-2025 |
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| container_end_page | 2025 |
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| container_issue | 7 |
| container_start_page | 2022 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 13 |
| creator | Usui, Kenji Okada, Arisa Kobayashi, Keita Sugimoto, Naoki |
| description | We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadruplex-related important biological events. |
| doi_str_mv | 10.1039/c4ob02535k |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2015-02, Vol.13 (7), p.2022-2025 |
| issn | 1477-0520 1477-0539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1660411716 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | DNA - chemistry DNA - metabolism Enzyme Activation Fluorescence Guanine - chemistry Guanine - metabolism Nucleic Acid Conformation Peptide Hydrolases - metabolism Peptide Nucleic Acids - chemistry Peptide Nucleic Acids - metabolism Peptides - chemistry Peptides - metabolism |
| title | Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide |
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