Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadrupl...

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Veröffentlicht in:Organic & biomolecular chemistry 2015-02, Vol.13 (7), p.2022-2025
Hauptverfasser: Usui, Kenji, Okada, Arisa, Kobayashi, Keita, Sugimoto, Naoki
Format: Artikel
Sprache:eng
Schlagworte:
DNA - chemistry
DNA - metabolism
Enzyme Activation
Fluorescence
Guanine - chemistry
Guanine - metabolism
Nucleic Acid Conformation
Peptide Hydrolases - metabolism
Peptide Nucleic Acids - chemistry
Peptide Nucleic Acids - metabolism
Peptides - chemistry
Peptides - metabolism
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Beschreibung
Zusammenfassung:We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadruplex-related important biological events.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob02535k