Cerebral hemodynamic response to acute hyperoxia in awake mice

Abstract Cerebral hemodynamic response to acute hyperoxia was investigated in awake mice. Using laser-Doppler flowmetry (LDF), baseline cerebral blood flow (CBF) and the cerebrovascular responses to whisker stimulation were measured in awake mice during normoxia and hyperoxia. Using two-photon laser...

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Veröffentlicht in:	Brain research 2014-04, Vol.1557, p.155-163
Hauptverfasser:	Tajima, Yosuke, Takuwa, Hiroyuki, Nishino, Asuka, Matsuura, Tetsuya, Kawaguchi, Hiroshi, Ikoma, Yoko, Taniguchi, Junko, Seki, Chie, Masamoto, Kazuto, Kanno, Iwao, Saeki, Naokatsu, Ito, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute hyperoxia Animals Arterioles - physiopathology Biological and medical sciences Blood Gas Analysis Blood Volume - physiology Capillaries - physiopathology Cerebral blood flow Cerebrovascular Circulation - physiology Fundamental and applied biological sciences. Psychology Hyperoxia - physiopathology Laser-Doppler Flowmetry Male Mice Mice, Inbred C57BL Mouse Neural activation Neurology Oxygen Consumption - physiology Physical Stimulation Somatosensory Cortex - blood supply Somatosensory Cortex - physiopathology Touch Perception - physiology Two-photon laser scanning microscopy Vasoconstriction - physiology Vertebrates: nervous system and sense organs Vibrissae - physiology Wakefulness - physiology
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Zusammenfassung:	Abstract Cerebral hemodynamic response to acute hyperoxia was investigated in awake mice. Using laser-Doppler flowmetry (LDF), baseline cerebral blood flow (CBF) and the cerebrovascular responses to whisker stimulation were measured in awake mice during normoxia and hyperoxia. Using two-photon laser scanning microscopy (TPLSM), the changes in cortical microvasculature were measured during normoxia and hyperoxia. During hyperoxia ( Pa O2 =482.3±19.7 mmHg), baseline CBF was 6.8% lower than normoxia ( Pa O2 =97.3±6.0 mmHg). The degree of increase in CBF evoked by whisker stimulation was greater during hyperoxia (18.1±5.0%) than normoxia (13.1±3.5%) ( P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2014.01.053