Safety and immunogenicity of a quadrivalent intradermal influenza vaccine in adults

Safety and immunogenicity of a quadrivalent intradermal influenza vaccine in adults

Highlights • Intradermal quadrivalent influenza vaccine (IIV4-ID) was as immunogenic as trivalent vaccines. • IIV4-ID induced superior antibody responses to the B strain not contained in the trivalent vaccine. • A second B strain in IIV4-ID did not change the safety profile compared with trivalent v...

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Veröffentlicht in:Vaccine 2015-02, Vol.33 (9), p.1151-1159
Hauptverfasser: Gorse, Geoffrey J, Falsey, Ann R, Ozol-Godfrey, Ayca, Landolfi, Victoria, Tsang, Peter H
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Adults
Age
Allergy and Immunology
Antibodies, Viral - blood
ClinicalTrials.gov no. NCT01712984
Double-Blind Method
Drug-Related Side Effects and Adverse Reactions - epidemiology
Drug-Related Side Effects and Adverse Reactions - pathology
Female
Hemagglutination Inhibition Tests
Humans
Immunization
Immunogenicity
Influenza
Influenza Vaccines - administration & dosage
Influenza Vaccines - adverse effects
Influenza Vaccines - immunology
Injections, Intradermal
Intradermal
Male
Middle Aged
Phase III
Quadrivalent influenza vaccine
Safety
Seasons
United States
Vaccines
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - adverse effects
Vaccines, Inactivated - immunology
Young Adult
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Beschreibung
Zusammenfassung:Highlights • Intradermal quadrivalent influenza vaccine (IIV4-ID) was as immunogenic as trivalent vaccines. • IIV4-ID induced superior antibody responses to the B strain not contained in the trivalent vaccine. • A second B strain in IIV4-ID did not change the safety profile compared with trivalent vaccines. • Injection site and systemic reactions were mostly grades 1 and 2 and transient. • IIV4-ID may reduce the risk of trivalent vaccine B strain mismatches with the circulating B strain.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.01.025