Neuroprotective effects of salvianolic acid B on an A beta sub(25-35) peptide-induced mouse model of Alzheimer's disease

Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that has several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether SalB has neuroprotective effects in an amyloid beta (A beta ) peptide-induced Alzheimer's disease...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2013-03, Vol.704 (1-3), p.70-77
Hauptverfasser:	Lee, Young Woo, Kim, Dong Hyun, Jeon, Su Jin, Park, Se Jin, Kim, Jong Min, Jung, Jun Man, Lee, Hyung Eun, Bae, Shin Gil, Oh, Hee Kyong, Son, Kun Ho Ho, Ryu, Jong Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Salvia miltiorrhiza
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that has several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether SalB has neuroprotective effects in an amyloid beta (A beta ) peptide-induced Alzheimer's disease mouse model. Mice were injected with A beta sub(25-35) peptide intracerebroventricularly and were subsequently administered SalB once daily for 7 days. Subchronic SalB administration (10 mg/kg) significantly ameliorated the A beta sub(25-35) peptide-induced memory impairment in the passive avoidance task (P
ISSN:	0014-2999
DOI:	10.1016/j.ejphar.2013.02.015